HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound PAR

Identifiers

  • Canonical SMILES: 
    NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)[C@H](N)[C@@H](O)[C@@H]1O
  • IUPAC name: 
    (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
  • InChi: 
    InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
  • InChiKey: 
    UOZODPSAJZTQNH-LSWIJEOBSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

165580 CHEMBL370143 DB01421

RNA-SM complexes

PDB code Deposition date Reference publication
4tud June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
4v5y June 19, 2007 Borovinskaya Maria A, Pai Raj D, Zhang Wen, Schuwirth Barbara S, Holton James M, Hirokawa Go, Kaji Hideko, Kaji Akira, Cate Jamie H Doudna. . Structural basis for aminoglycoside inhibition of bacterial ribosome recycling Nature Structural & Molecular Biology
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
8oeq March 12, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4v8j Dec. 20, 2011 Fagan Crystal E., Dunkle Jack A., Maehigashi Tatsuya, Dang Mai N., Devaraj Aishwarya, Miles Stacey J., Qin Daoming, Fredrick Kurt, Dunham Christine M.. . Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state Proceedings of the National Academy of Sciences
4v5y June 19, 2007 Borovinskaya Maria A, Pai Raj D, Zhang Wen, Schuwirth Barbara S, Holton James M, Hirokawa Go, Kaji Hideko, Kaji Akira, Cate Jamie H Doudna. . Structural basis for aminoglycoside inhibition of bacterial ribosome recycling Nature Structural & Molecular Biology
5br8 May 29, 2015
4wsd Oct. 27, 2014 Rozov Alexey, Demeshkina Natalia, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Structural insights into the translational infidelity mechanism Nature Communications
4lf8 June 26, 2013
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
6mkn Sept. 25, 2018 Vangaveti Sweta, Cantara William A., Spears Jessica L., DeMirci Hasan, Murphy Frank V., Ranganathan Sri V., Sarachan Kathryn L., Agris Paul F.. . A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine Journal of Molecular Biology
5br8 May 29, 2015
4v5g Sept. 1, 2009 Schmeing T. Martin, Voorhees Rebecca M., Kelley Ann C., Gao Yong-Gui, Murphy Frank V., Weir John R., Ramakrishnan V.. . The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA Science
4lsk July 22, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4jya March 29, 2013 Fernández Israel S., Ng Chyan Leong, Kelley Ann C., Wu Guowei, Yu Yi-Tao, Ramakrishnan V.. . Unusual base pairing during the decoding of a stop codon by the ribosome Nature
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4gkj Aug. 11, 2012 Cantara William A., Murphy Frank V., Demirci Hasan, Agris Paul F.. . Expanded use of sense codons is regulated by modified cytidines in tRNA Proceedings of the National Academy of Sciences
2uxb March 28, 2007 Dunham Christine M., Selmer Maria, Phelps Steven S., Kelley Ann C., Suzuki Tsutomu, Joseph Simpson, Ramakrishnan V.. . Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit RNA
4v8c Dec. 7, 2011 Demeshkina Natalia, Jenner Lasse, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . A new understanding of the decoding principle on the ribosome Nature
4x65 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
3bnq Dec. 14, 2007 Kondo Jiro, Westhof Eric. . The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates Nucleic Acids Research
6cao Jan. 31, 2018 Dao E. Han, Poitevin Frédéric, Sierra Raymond G., Gati Cornelius, Rao Yashas, Ciftci Halil Ibrahim, Akşit Fulya, McGurk Alex, Obrinski Trevor, Mgbam Paul, Hayes Brandon, De Lichtenberg Casper, Pardo-Avila Fatima, Corsepius Nicholas, Zhang Lindsey, Seaberg Matthew H., Hunter Mark S., Liang Mengling, Koglin Jason E., Wakatsuki Soichi, Demirci Hasan. . Structure of the 30S ribosomal decoding complex at ambient temperature RNA
1xnq Oct. 5, 2004 Murphy Frank V, Ramakrishnan V. . Structure of a purine-purine wobble base pair in the decoding center of the ribosome Nature Structural & Molecular Biology
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4lt8 July 23, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4v5d March 24, 2009 Voorhees Rebecca M, Weixlbaumer Albert, Loakes David, Kelley Ann C, Ramakrishnan V. . Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome Nature Structural & Molecular Biology
5el6 Nov. 4, 2015 Rozov Alexey, Demeshkina Natalia, Khusainov Iskander, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code Nature Communications
1n32 Oct. 25, 2002 Ogle James M., Murphy Frank V., Tarry Michael J., Ramakrishnan V.. . Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form Cell
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4p70 March 25, 2014 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4v8c Dec. 7, 2011 Demeshkina Natalia, Jenner Lasse, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . A new understanding of the decoding principle on the ribosome Nature
4lf7 June 26, 2013
2mxs Jan. 14, 2015 Duchardt‐Ferner Elke, Gottstein‐Schmidtke Sina R., Weigand Julia E., Ohlenschläger Oliver, Wurm Jan‐Philip, Hammann Christian, Suess Beatrix, Wöhnert Jens. . What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin‐Sensing Riboswitch Angewandte Chemie International Edition
8oeq March 12, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4wra Oct. 23, 2014 Rozov Alexey, Demeshkina Natalia, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Structural insights into the translational infidelity mechanism Nature Communications
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
6dti June 16, 2018 Vangaveti Sweta, Cantara William A., Spears Jessica L., DeMirci Hasan, Murphy Frank V., Ranganathan Sri V., Sarachan Kathryn L., Agris Paul F.. . A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine Journal of Molecular Biology
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4x62 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
4tud June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
2uxc March 28, 2007 Dunham Christine M., Selmer Maria, Phelps Steven S., Kelley Ann C., Suzuki Tsutomu, Joseph Simpson, Ramakrishnan V.. . Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit RNA
4wt8 Oct. 29, 2014 Amunts Alexey, Fiedorczuk Karol, Truong Thao T., Chandler Josephine, Greenberg E. Peter, Ramakrishnan V.. . Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics Journal of Molecular Biology
4wra Oct. 23, 2014 Rozov Alexey, Demeshkina Natalia, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Structural insights into the translational infidelity mechanism Nature Communications
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
2uxd March 28, 2007 Dunham Christine M., Selmer Maria, Phelps Steven S., Kelley Ann C., Suzuki Tsutomu, Joseph Simpson, Ramakrishnan V.. . Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit RNA
8oeq March 12, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
1n33 Oct. 25, 2002 Ogle James M., Murphy Frank V., Tarry Michael J., Ramakrishnan V.. . Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form Cell
8g7q Feb. 16, 2023 Rybak Mariia Yu., Gagnon Matthieu G.. . Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance Nature Structural & Molecular Biology
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
8g6w Feb. 16, 2023 Majumdar Chandrima, Walker Joshua A., Francis Matthew B., Schepartz Alanna, Cate Jamie H. D.. . Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome ACS Central Science
4tua June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
8eiu Sept. 15, 2022 Nissley Amos J, Penev Petar I, Watson Zoe L, Banfield Jillian F, Cate Jamie H D. . Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome Nucleic Acids Research
4khp May 1, 2013 Tourigny David S., Fernández Israel S., Kelley Ann C., Vakiti Ramkrishna Reddy, Chattopadhyay Amit Kumar, Dorich Stéphane, Hanessian Stephen, Ramakrishnan V.. . Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit Journal of Molecular Biology
4lt8 July 23, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4x66 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
2uu9 March 1, 2007 Weixlbaumer Albert, Murphy Frank V, Dziergowska Agnieszka, Malkiewicz Andrzej, Vendeix Franck A P, Agris Paul F, Ramakrishnan V. . Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines Nature Structural & Molecular Biology
3t1h July 21, 2011 Vendeix Franck A.P., Murphy Frank V., Cantara William A., Leszczyńska Grażyna, Gustilo Estella M., Sproat Brian, Malkiewicz Andrzej, Agris Paul F.. . Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism Journal of Molecular Biology
3t1y July 22, 2011 Vendeix Franck A.P., Murphy Frank V., Cantara William A., Leszczyńska Grażyna, Gustilo Estella M., Sproat Brian, Malkiewicz Andrzej, Agris Paul F.. . Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism Journal of Molecular Biology
4x66 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
4v5c March 24, 2009 Voorhees Rebecca M, Weixlbaumer Albert, Loakes David, Kelley Ann C, Ramakrishnan V. . Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome Nature Structural & Molecular Biology
6az3 Sept. 9, 2017 Shalev-Benami Moran, Zhang Yan, Rozenberg Haim, Nobe Yuko, Taoka Masato, Matzov Donna, Zimmerman Ella, Bashan Anat, Isobe Toshiaki, Jaffe Charles L., Yonath Ada, Skiniotis Georgios. . Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Nature Communications
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4zc7 April 15, 2015 Shalev Moran, Rozenberg Haim, Smolkin Boris, Nasereddin Abedelmajeed, Kopelyanskiy Dmitry, Belakhov Valery, Schrepfer Thomas, Schacht Jochen, Jaffe Charles L., Adir Noam, Baasov Timor. . Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics Nucleic Acids Research
4tub June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
5iqr March 11, 2016 Brown Alan, Fernández Israel S., Gordiyenko Yuliya, Ramakrishnan V.. . Ribosome-dependent activation of stringent control Nature
4v8f Dec. 7, 2011 Demeshkina Natalia, Jenner Lasse, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . A new understanding of the decoding principle on the ribosome Nature
4lf8 June 26, 2013
4khp May 1, 2013 Tourigny David S., Fernández Israel S., Kelley Ann C., Vakiti Ramkrishna Reddy, Chattopadhyay Amit Kumar, Dorich Stéphane, Hanessian Stephen, Ramakrishnan V.. . Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit Journal of Molecular Biology
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4x64 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
6of6 March 28, 2019 Nguyen Ha An, Sunita S., Dunham Christine M.. . Disruption of evolutionarily correlated tRNA elements impairs accurate decoding Proceedings of the National Academy of Sciences
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4p6f March 24, 2014 Washington Arren Z., Benicewicz Derek B., Canzoneri Joshua C., Fagan Crystal E., Mwakwari Sandra C., Maehigashi Tatsuya, Dunham Christine M., Oyelere Adegboyega K.. . Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome ACS Chemical Biology
6az3 Sept. 9, 2017 Shalev-Benami Moran, Zhang Yan, Rozenberg Haim, Nobe Yuko, Taoka Masato, Matzov Donna, Zimmerman Ella, Bashan Anat, Isobe Toshiaki, Jaffe Charles L., Yonath Ada, Skiniotis Georgios. . Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Nature Communications
4l47 June 7, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4v97 April 6, 2012 Fagan Crystal E., Dunkle Jack A., Maehigashi Tatsuya, Dang Mai N., Devaraj Aishwarya, Miles Stacey J., Qin Daoming, Fredrick Kurt, Dunham Christine M.. . Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state Proceedings of the National Academy of Sciences
4tue June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
4l47 June 7, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
1j7t May 18, 2001 Vicens Quentin, Westhof Eric. . Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site Structure
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4x64 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
4gkk Aug. 11, 2012 Cantara William A., Murphy Frank V., Demirci Hasan, Agris Paul F.. . Expanded use of sense codons is regulated by modified cytidines in tRNA Proceedings of the National Academy of Sciences
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
8emm Sept. 28, 2022 Watson Zoe L., Knudson Isaac J., Ward Fred R., Miller Scott J., Cate Jamie H. D., Schepartz Alanna, Abramyan Ara M.. . Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates Nature Chemistry
4v5y June 19, 2007 Borovinskaya Maria A, Pai Raj D, Zhang Wen, Schuwirth Barbara S, Holton James M, Hirokawa Go, Kaji Hideko, Kaji Akira, Cate Jamie H Doudna. . Structural basis for aminoglycoside inhibition of bacterial ribosome recycling Nature Structural & Molecular Biology
4v5g Sept. 1, 2009 Schmeing T. Martin, Voorhees Rebecca M., Kelley Ann C., Gao Yong-Gui, Murphy Frank V., Weir John R., Ramakrishnan V.. . The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA Science
1xmo Oct. 4, 2004 Murphy Frank V, Ramakrishnan Venki, Malkiewicz Andrzej, Agris Paul F. . The role of modifications in codon discrimination by tRNALysUUU Nature Structural & Molecular Biology
4tua June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
4khp May 1, 2013 Tourigny David S., Fernández Israel S., Kelley Ann C., Vakiti Ramkrishna Reddy, Chattopadhyay Amit Kumar, Dorich Stéphane, Hanessian Stephen, Ramakrishnan V.. . Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit Journal of Molecular Biology
4x66 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
4v5y June 19, 2007 Borovinskaya Maria A, Pai Raj D, Zhang Wen, Schuwirth Barbara S, Holton James M, Hirokawa Go, Kaji Hideko, Kaji Akira, Cate Jamie H Doudna. . Structural basis for aminoglycoside inhibition of bacterial ribosome recycling Nature Structural & Molecular Biology
4v51 July 31, 2006 Selmer Maria, Dunham Christine M., Murphy Frank V., Weixlbaumer Albert, Petry Sabine, Kelley Ann C., Weir John R., Ramakrishnan V.. . Structure of the 70 S Ribosome Complexed with mRNA and tRNA Science
1vvj May 24, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4lnt July 12, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4x62 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
4wt8 Oct. 29, 2014 Amunts Alexey, Fiedorczuk Karol, Truong Thao T., Chandler Josephine, Greenberg E. Peter, Ramakrishnan V.. . Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics Journal of Molecular Biology
6mpi Oct. 7, 2018 Vangaveti Sweta, Cantara William A., Spears Jessica L., DeMirci Hasan, Murphy Frank V., Ranganathan Sri V., Sarachan Kathryn L., Agris Paul F.. . A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine Journal of Molecular Biology
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4lf7 June 26, 2013
4zc7 April 15, 2015 Shalev Moran, Rozenberg Haim, Smolkin Boris, Nasereddin Abedelmajeed, Kopelyanskiy Dmitry, Belakhov Valery, Schrepfer Thomas, Schacht Jochen, Jaffe Charles L., Adir Noam, Baasov Timor. . Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics Nucleic Acids Research
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4v5d March 24, 2009 Voorhees Rebecca M, Weixlbaumer Albert, Loakes David, Kelley Ann C, Ramakrishnan V. . Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome Nature Structural & Molecular Biology
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
5ib7 Feb. 22, 2016 Rozov Alexey, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix Nucleic Acids Research
5el7 Nov. 4, 2015 Rozov Alexey, Demeshkina Natalia, Khusainov Iskander, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code Nature Communications
5el7 Nov. 4, 2015 Rozov Alexey, Demeshkina Natalia, Khusainov Iskander, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code Nature Communications
4v51 July 31, 2006 Selmer Maria, Dunham Christine M., Murphy Frank V., Weixlbaumer Albert, Petry Sabine, Kelley Ann C., Weir John R., Ramakrishnan V.. . Structure of the 70 S Ribosome Complexed with mRNA and tRNA Science
1fyp Oct. 2, 2000 Lynch Stephen R, Puglisi Joseph D. . Structural origins of aminoglycoside specificity for prokaryotic ribosomes Journal of Molecular Biology
4v5c March 24, 2009 Voorhees Rebecca M, Weixlbaumer Albert, Loakes David, Kelley Ann C, Ramakrishnan V. . Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome Nature Structural & Molecular Biology
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
6ord April 30, 2019 Nguyen Ha An, Sunita S., Dunham Christine M.. . Disruption of evolutionarily correlated tRNA elements impairs accurate decoding Proceedings of the National Academy of Sciences
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
2uub March 1, 2007 Weixlbaumer Albert, Murphy Frank V, Dziergowska Agnieszka, Malkiewicz Andrzej, Vendeix Franck A P, Agris Paul F, Ramakrishnan V. . Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines Nature Structural & Molecular Biology
7oiz May 13, 2021 Su Ting, Kudva Renuka, Becker Thomas, Buschauer Robert, Komar Tobias, Berninghausen Otto, von Heijne Gunnar, Cheng Jingdong, Beckmann Roland. . Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide Nucleic Acids Research
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
6oj2 April 10, 2019 Nguyen Ha An, Sunita S., Dunham Christine M.. . Disruption of evolutionarily correlated tRNA elements impairs accurate decoding Proceedings of the National Academy of Sciences
6mpf Oct. 5, 2018 Vangaveti Sweta, Cantara William A., Spears Jessica L., DeMirci Hasan, Murphy Frank V., Ranganathan Sri V., Sarachan Kathryn L., Agris Paul F.. . A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine Journal of Molecular Biology
6oj2 April 10, 2019 Nguyen Ha An, Sunita S., Dunham Christine M.. . Disruption of evolutionarily correlated tRNA elements impairs accurate decoding Proceedings of the National Academy of Sciences
4lnt July 12, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
1j7t May 18, 2001 Vicens Quentin, Westhof Eric. . Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site Structure
4dr4 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
2vqe March 13, 2008 Kurata Shinya, Weixlbaumer Albert, Ohtsuki Takashi, Shimazaki Tomomi, Wada Takeshi, Kirino Yohei, Takai Kazuyuki, Watanabe Kimitsuna, Ramakrishnan V., Suzuki Tsutomu. . Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding Journal of Biological Chemistry
2o3w Dec. 2, 2006 Kondo Jiro, Hainrichson Mariana, Nudelman Igor, Shallom‐Shezifi Dalia, Barbieri Christopher M., Pilch Daniel S., Westhof Eric, Baasov Timor. . Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites ChemBioChem
4x65 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
5tcu Sept. 15, 2016 Belousoff Matthew J., Eyal Zohar, Radjainia Mazdak, Ahmed Tofayel, Bamert Rebecca S., Matzov Donna, Bashan Anat, Zimmerman Ella, Mishra Satabdi, Cameron David, Elmlund Hans, Peleg Anton Y., Bhushan Shashi, Lithgow Trevor, Yonath Ada. . Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome mBio
4lsk July 22, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
5br8 May 29, 2015
6cao Jan. 31, 2018 Dao E. Han, Poitevin Frédéric, Sierra Raymond G., Gati Cornelius, Rao Yashas, Ciftci Halil Ibrahim, Akşit Fulya, McGurk Alex, Obrinski Trevor, Mgbam Paul, Hayes Brandon, De Lichtenberg Casper, Pardo-Avila Fatima, Corsepius Nicholas, Zhang Lindsey, Seaberg Matthew H., Hunter Mark S., Liang Mengling, Koglin Jason E., Wakatsuki Soichi, Demirci Hasan. . Structure of the 30S ribosomal decoding complex at ambient temperature RNA
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4l71 June 13, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
4lel June 25, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
1vvj May 24, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
2uua March 1, 2007 Weixlbaumer Albert, Murphy Frank V, Dziergowska Agnieszka, Malkiewicz Andrzej, Vendeix Franck A P, Agris Paul F, Ramakrishnan V. . Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines Nature Structural & Molecular Biology
2vqf March 14, 2008 Kurata Shinya, Weixlbaumer Albert, Ohtsuki Takashi, Shimazaki Tomomi, Wada Takeshi, Kirino Yohei, Takai Kazuyuki, Watanabe Kimitsuna, Ramakrishnan V., Suzuki Tsutomu. . Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding Journal of Biological Chemistry
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4tue June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4x62 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
1ibk March 28, 2001 Ogle James M., Brodersen Ditlev E., Clemons William M., Tarry Michael J., Carter Andrew P., Ramakrishnan V.. . Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit Science
4l71 June 13, 2013 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
7k00 Sept. 2, 2020 Watson Zoe L, Ward Fred R, Méheust Raphaël, Ad Omer, Schepartz Alanna, Banfield Jillian F, Cate Jamie HD. . Structure of the bacterial ribosome at 2 Å resolution eLife
4lf8 June 26, 2013
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4tub June 24, 2014 Fagan Crystal E., Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into translational recoding by frameshift suppressor tRNASufJ RNA
8g7r Feb. 16, 2023 Rybak Mariia Yu., Gagnon Matthieu G.. . Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance Nature Structural & Molecular Biology
6az1 Sept. 9, 2017 Shalev-Benami Moran, Zhang Yan, Rozenberg Haim, Nobe Yuko, Taoka Masato, Matzov Donna, Zimmerman Ella, Bashan Anat, Isobe Toshiaki, Jaffe Charles L., Yonath Ada, Skiniotis Georgios. . Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Nature Communications
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
1xnr Oct. 5, 2004 Murphy Frank V, Ramakrishnan V. . Structure of a purine-purine wobble base pair in the decoding center of the ribosome Nature Structural & Molecular Biology
4p70 March 25, 2014 Maehigashi Tatsuya, Dunkle Jack A., Miles Stacey J., Dunham Christine M.. . Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops Proceedings of the National Academy of Sciences
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
6az3 Sept. 9, 2017 Shalev-Benami Moran, Zhang Yan, Rozenberg Haim, Nobe Yuko, Taoka Masato, Matzov Donna, Zimmerman Ella, Bashan Anat, Isobe Toshiaki, Jaffe Charles L., Yonath Ada, Skiniotis Georgios. . Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Nature Communications
4wsd Oct. 27, 2014 Rozov Alexey, Demeshkina Natalia, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Structural insights into the translational infidelity mechanism Nature Communications
4x65 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
8oi5 March 22, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
5el6 Nov. 4, 2015 Rozov Alexey, Demeshkina Natalia, Khusainov Iskander, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code Nature Communications
4v97 April 6, 2012 Fagan Crystal E., Dunkle Jack A., Maehigashi Tatsuya, Dang Mai N., Devaraj Aishwarya, Miles Stacey J., Qin Daoming, Fredrick Kurt, Dunham Christine M.. . Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state Proceedings of the National Academy of Sciences
8oh6 March 20, 2023 Kolosova Olga, Zgadzay Yury, Stetsenko Artem, Sukhinina Anastasia P., Atamas Anastasia, Validov Shamil, Rogachev Andrey, Usachev Konstantin, Jenner Lasse, Dmitriev Sergey E., Yusupova Gulnara, Guskov Albert, Yusupov Marat. . Mechanism of read-through enhancement by aminoglycosides and mefloquine Proceedings of the National Academy of Sciences
4lf7 June 26, 2013
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
3bnr Dec. 14, 2007 Kondo Jiro, Westhof Eric. . The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates Nucleic Acids Research
6az1 Sept. 9, 2017 Shalev-Benami Moran, Zhang Yan, Rozenberg Haim, Nobe Yuko, Taoka Masato, Matzov Donna, Zimmerman Ella, Bashan Anat, Isobe Toshiaki, Jaffe Charles L., Yonath Ada, Skiniotis Georgios. . Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Nature Communications
4woi Oct. 15, 2014 Wasserman Michael R., Pulk Arto, Zhou Zhou, Altman Roger B., Zinder John C., Green Keith D., Garneau-Tsodikova Sylvie, Doudna Cate Jamie H., Blanchard Scott C.. . Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions Nature Communications
4v8f Dec. 7, 2011 Demeshkina Natalia, Jenner Lasse, Westhof Eric, Yusupov Marat, Yusupova Gulnara. . A new understanding of the decoding principle on the ribosome Nature
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
1ibl March 28, 2001 Ogle James M., Brodersen Ditlev E., Clemons William M., Tarry Michael J., Carter Andrew P., Ramakrishnan V.. . Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit Science
5zej Feb. 27, 2018 Kanazawa Hiroki, Baba Fumika, Koganei Mai, Kondo Jiro. . A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA Nucleic Acids Research
4dr2 Feb. 16, 2012 Demirci Hasan, Murphy Frank, Murphy Eileen, Gregory Steven T., Dahlberg Albert E., Jogl Gerwald. . A structural basis for streptomycin-induced misreading of the genetic code Nature Communications
4x64 Dec. 6, 2014 Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. . N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology
5ndv March 9, 2017 Prokhorova Irina, Altman Roger B., Djumagulov Muminjon, Shrestha Jaya P., Urzhumtsev Alexandre, Ferguson Angelica, Chang Cheng-Wei Tom, Yusupov Marat, Blanchard Scott C., Yusupova Gulnara. . Aminoglycoside interactions and impacts on the eukaryotic ribosome Proceedings of the National Academy of Sciences
4v8j Dec. 20, 2011 Fagan Crystal E., Dunkle Jack A., Maehigashi Tatsuya, Dang Mai N., Devaraj Aishwarya, Miles Stacey J., Qin Daoming, Fredrick Kurt, Dunham Christine M.. . Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state Proceedings of the National Academy of Sciences
4p6f March 24, 2014 Washington Arren Z., Benicewicz Derek B., Canzoneri Joshua C., Fagan Crystal E., Mwakwari Sandra C., Maehigashi Tatsuya, Dunham Christine M., Oyelere Adegboyega K.. . Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome ACS Chemical Biology
2uuc March 1, 2007 Weixlbaumer Albert, Murphy Frank V, Dziergowska Agnieszka, Malkiewicz Andrzej, Vendeix Franck A P, Agris Paul F, Ramakrishnan V. . Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines Nature Structural & Molecular Biology
6of6 March 28, 2019 Nguyen Ha An, Sunita S., Dunham Christine M.. . Disruption of evolutionarily correlated tRNA elements impairs accurate decoding Proceedings of the National Academy of Sciences

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 615.30 g/mol
HBA 19
HBD 13
HBA + HBD
AlogP -8.86
TPSA 347.32
RB 9

Radar chart