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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2uxc

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.90
System mass 797.41 kDa
Deposition year 2007
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 2uxc
Reference Dunham Christine M., Selmer Maria, Phelps Steven S., Kelley Ann C., Suzuki Tsutomu, Joseph Simpson, Ramakrishnan V.. 2007. Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit RNA
Equivalence Class NR_all_65795.87
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 2001
Chain X / A
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 284.69 Å3
Hydrophobicity 0.187
Hydrophilicity 1.035
Buriedness 0.661
Don/acc character 1.793
SiteScore 1.112
D Score 0.980
Kd