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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5iqr

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 2339.19 kDa
Deposition year 2016
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 5iqr
Reference Brown Alan, Fernández Israel S., Gordiyenko Yuliya, Ramakrishnan V.. 2016. Ribosome-dependent activation of stringent control Nature
Equivalence Class NR_all_56726.172
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 1665
Chain PM / 2
Non-redundant True
Interacting RNA chains AB/2
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains AB/2: rRNA
RNA family global rRNA
Volume 352.26 Å3
Hydrophobicity 0.011
Hydrophilicity 1.186
Buriedness 0.686
Don/acc character 2.305
SiteScore 0.922
D Score 0.683
Kd