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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9v26

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.10
System mass 3174.41 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Entamoeba
RCSB PDB Entry 9v26
Reference Sharma Shivani, Mishra Shalini, Gourinath Samudrala, Kaushal Prem S.. 2025. Cryo-EM structure of ribosome from pathogenic protozoa Entamoeba histolytica reveals unique features of its architecture Nature Communications
Equivalence Class NR_all_75722.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 5101
Chain WB / sa
Non-redundant True
Interacting RNA chains ZA/sa
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains ZA/sa: rRNA
RNA family global rRNA
Volume 249.02 Å3
Hydrophobicity 0.069
Hydrophilicity 0.996
Buriedness 0.645
Don/acc character 1.159
SiteScore 1.003
D Score 0.849
Kd