Complex 4x64
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.35 |
| System mass | 785.87 kDa |
| Deposition year | 2014 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermus |
| RCSB PDB Entry | 4x64 |
| Reference | Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. 2016. N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology |
| Equivalence Class |
NR_all_65795.87
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | PAR |
| Residue | . / 1601 |
| Chain | X / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 287.43 Å3 |
| Hydrophobicity | 0.118 |
| Hydrophilicity | 0.898 |
| Buriedness | 0.636 |
| Don/acc character | 3.055 |
| SiteScore | 0.750 |
| D Score | 0.726 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1602 |
| Chain | Y / A |
| Non-redundant | True |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 209.92 Å3 |
| Hydrophobicity | 0.133 |
| Hydrophilicity | 1.168 |
| Buriedness | 0.805 |
| Don/acc character | 3.060 |
| SiteScore | 0.712 |
| D Score | 0.581 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1603 |
| Chain | Z / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 474.71 Å3 |
| Hydrophobicity | 0.173 |
| Hydrophilicity | 1.493 |
| Buriedness | 0.811 |
| Don/acc character | 1.282 |
| SiteScore | 1.021 |
| D Score | 0.678 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1604 |
| Chain | AA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 574.53 Å3 |
| Hydrophobicity | 0.146 |
| Hydrophilicity | 1.395 |
| Buriedness | 0.710 |
| Don/acc character | 1.421 |
| SiteScore | 1.008 |
| D Score | 0.911 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1605 |
| Chain | BA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 734.71 Å3 |
| Hydrophobicity | 0.125 |
| Hydrophilicity | 1.635 |
| Buriedness | 0.729 |
| Don/acc character | 0.825 |
| SiteScore | 1.021 |
| D Score | 0.844 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1606 |
| Chain | CA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 44.93 Å3 |
| Hydrophobicity | 0.000 |
| Hydrophilicity | 2.036 |
| Buriedness | 0.881 |
| Don/acc character | 1.398 |
| SiteScore | 0.891 |
| D Score | 0.316 |
| Kd | — |