Complex 4x62
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.45 |
| System mass | 784.71 kDa |
| Deposition year | 2014 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermus |
| RCSB PDB Entry | 4x62 |
| Reference | Choi Junhong, Ieong Ka-Weng, Demirci Hasan, Chen Jin, Petrov Alexey, Prabhakar Arjun, O'Leary Seán E, Dominissini Dan, Rechavi Gideon, Soltis S Michael, Ehrenberg Måns, Puglisi Joseph D. 2016. N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics Nature Structural & Molecular Biology |
| Equivalence Class |
NR_all_65795.87
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | PAR |
| Residue | . / 1601 |
| Chain | X / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 120.74 Å3 |
| Hydrophobicity | 0.147 |
| Hydrophilicity | 0.886 |
| Buriedness | 0.623 |
| Don/acc character | 3.182 |
| SiteScore | 0.668 |
| D Score | 0.625 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1602 |
| Chain | Y / A |
| Non-redundant | True |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 150.23 Å3 |
| Hydrophobicity | 0.044 |
| Hydrophilicity | 1.400 |
| Buriedness | 0.814 |
| Don/acc character | 3.017 |
| SiteScore | 0.587 |
| D Score | 0.344 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1603 |
| Chain | Z / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 508.33 Å3 |
| Hydrophobicity | 0.105 |
| Hydrophilicity | 1.446 |
| Buriedness | 0.808 |
| Don/acc character | 1.153 |
| SiteScore | 1.047 |
| D Score | 0.717 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1604 |
| Chain | AA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 625.63 Å3 |
| Hydrophobicity | 0.172 |
| Hydrophilicity | 1.453 |
| Buriedness | 0.712 |
| Don/acc character | 1.426 |
| SiteScore | 1.009 |
| D Score | 0.893 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1605 |
| Chain | BA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 629.41 Å3 |
| Hydrophobicity | 0.012 |
| Hydrophilicity | 1.886 |
| Buriedness | 0.733 |
| Don/acc character | 0.778 |
| SiteScore | 1.023 |
| D Score | 0.765 |
| Kd | — |
| Compound | PAR |
| Residue | . / 1606 |
| Chain | CA / A |
| Non-redundant | False |
| Interacting RNA chains | A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA |
| RNA family global | rRNA |
| Volume | 55.57 Å3 |
| Hydrophobicity | 0.000 |
| Hydrophilicity | 1.911 |
| Buriedness | 0.871 |
| Don/acc character | 1.091 |
| SiteScore | 0.899 |
| D Score | 0.370 |
| Kd | — |