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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1j7t

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.50
System mass 15.33 kDa
Deposition year 2001
Molecule type RNA
# RNA entities 1
Organism N/A
RCSB PDB Entry 1j7t
Reference Vicens Quentin, Westhof Eric. 2001. Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site Structure
Equivalence Class NR_all_71199.7
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 45
Chain C / A
Non-redundant True
Interacting RNA chains B/B, A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA, B/B: rRNA
RNA family global rRNA
Volume 75.80 Å3
Hydrophobicity 0.104
Hydrophilicity 0.856
Buriedness 0.571
Don/acc character 3.992
SiteScore 0.776
D Score 0.587
Kd

Compound PAR
Residue . / 46
Chain D / B
Non-redundant True
Interacting RNA chains B/B, A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA, B/B: rRNA
RNA family global rRNA
Volume 103.59 Å3
Hydrophobicity 0.130
Hydrophilicity 0.779
Buriedness 0.561
Don/acc character 3.836
SiteScore 0.839
D Score 0.677
Kd