Harnessing RIBOnucleic acid - Small molecules Structures


HARIBOSS is a curated database of RNA-small molecules structures retrieved from the PDB. HARIBOSS is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS provides researchers with a tool to aid the development of rational design strategies to target RNA with small molecules.

Latest paper : HARIBOSS: a curated database of RNA-small molecules structures to aid rational drug design

Explore database


Francesco Paolo Panei

Francesco Paolo Panei is a PhD student at Institut Pasteur (Paris, France) and Sanofi (Chilly-Mazarin, France) since 2021. Francesco has a background in theoretical physics and he is interested in applying its methods to tackle relevant biological problems, especially related to therapeutic applications.

Read more
Evi Gkeka

Evi Gkeka is an applied mathematician and computational chemist with more than 15 years of research experience in molecular modeling. She has been member of the computer-aided drug design group at Sanofi R&D since 2016. Her work is focused on the development and application of computational methods that can revolutionize drug discovery.

Read more
Max Bonomi

Max Bonomi is a CNRS researcher and group leader at Institut Pasteur (Paris, France). His research group is focused on the development and application of integrative computational/experimental approaches to study structural and dynamic properties of biological systems. More info can be found here.

Read more