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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1n32

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.00
System mass 794.34 kDa
Deposition year 2002
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 1n32
Reference Ogle James M., Murphy Frank V., Tarry Michael J., Ramakrishnan V.. 2002. Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form Cell
Equivalence Class NR_all_65795.87
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 1545
Chain X / A
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 438.35 Å3
Hydrophobicity 0.077
Hydrophilicity 1.053
Buriedness 0.646
Don/acc character 2.044
SiteScore 1.104
D Score 0.970
Kd