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HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7k00

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 1.98
System mass 2209.99 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7k00
Reference Watson Zoe L, Ward Fred R, Méheust Raphaël, Ad Omer, Schepartz Alanna, Banfield Jillian F, Cate Jamie HD. 2020. Structure of the bacterial ribosome at 2 Å resolution eLife
Equivalence Class NR_all_83717.187, NR_all_56726.172
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 1601
Chain EB / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 263.77 Å3
Hydrophobicity 0.122
Hydrophilicity 0.976
Buriedness 0.684
Don/acc character 2.155
SiteScore 0.852
D Score 0.838
Kd

Compound SPM
Residue . / 6223
Chain KN / a
Non-redundant True
Interacting RNA chains V/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains V/a: rRNA
RNA family global rRNA
Volume 280.92 Å3
Hydrophobicity 0.213
Hydrophilicity 1.141
Buriedness 0.742
Don/acc character 1.223
SiteScore 0.995
D Score 0.777
Kd