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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7oiz

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.90
System mass 2120.28 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7oiz
Reference Su Ting, Kudva Renuka, Becker Thomas, Buschauer Robert, Komar Tobias, Berninghausen Otto, von Heijne Gunnar, Cheng Jingdong, Beckmann Roland. 2021. Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide Nucleic Acids Research
Equivalence Class NR_all_83717.187, NR_all_56726.172, NR_all_56633.10
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 1601
Chain DB / A
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 252.45 Å3
Hydrophobicity 0.306
Hydrophilicity 1.114
Buriedness 0.692
Don/acc character 1.505
SiteScore 1.100
D Score 0.934
Kd

Compound TRP
Residue . / 6206
Chain QM / a
Non-redundant True
Interacting RNA chains V/a
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains V/a: rRNA
RNA family global rRNA
Volume 446.24 Å3
Hydrophobicity 0.412
Hydrophilicity 1.313
Buriedness 0.775
Don/acc character 0.849
SiteScore 1.051
D Score 0.977
Kd