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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9o2x

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.29
System mass 2208.96 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 9o2x
Reference Majumdar Chandrima, Kent Alexandra D., Hamlish Noah X., Zhu Cathy, Fitzgerald Katelyn A., Cate Jamie H.D., Schepartz Alanna. 2026. Co-Translational Incorporation of (R) - and (S)2 -Hydroxy Acids In Vitro : A Structural and Biochemical Study on the E. coli Ribosome Journal of the American Chemical Society
Equivalence Class NR_all_83717.187, NR_all_56726.172
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound PAR
Residue . / 1601
Chain RB / A
Non-redundant True
Interacting RNA chains ZA/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains ZA/A: rRNA
RNA family global rRNA
Volume 253.48 Å3
Hydrophobicity 0.108
Hydrophilicity 0.982
Buriedness 0.685
Don/acc character 2.305
SiteScore 0.832
D Score 0.813
Kd

Compound SPM
Residue . / 3220
Chain QN / a
Non-redundant True
Interacting RNA chains AB/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains AB/a: rRNA
RNA family global rRNA
Volume 337.17 Å3
Hydrophobicity 0.213
Hydrophilicity 1.040
Buriedness 0.744
Don/acc character 1.225
SiteScore 1.016
D Score 0.835
Kd