Harnessing RIBOnucleic acid - Small molecules Structures
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Structure of 30S-IF1-IF3-mRNA-GE81112A complex
SM: A1IC4
CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1
SM: 3HE ANM GDP HYG
Assembly intermediate of human mitochondrial ribosome small subunit (State C)
SM: NAD
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA with h44 in up position
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA with h44 in up position
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
The structure of the Candida albicans ribosome with tRNA-fMet, mRNA, and compounds (GEN and MFQ) with strong density for the P-site tRNA
SM: GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET SPK YMZ
Fusidic acid-locked Escherichia coli 70S ribosome with Staphylococcus aureus EF-G and a tRNA in pe/E chimeric state (CHI)
SM: FUA
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aEF1A-like mRNA
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-SITE TRNA AND MRNA : LM32CS1C1 M2 OE MUTANT
SM: PAR PAR PAR PAR PAR PAR
Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA
SM: SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM
Structure of 30S-IF1-IF3-mRNA-fMet-tRNA-GE81112A complex
Structure of Candida albicans 80S ribosome in complex with mefloquine (non-rotated state)
SM: SPK YMZ YMZ
eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16
SM: EPE
Mtb PNPase Rv2783c
SM: A1IM2 A1IM2 A1IM2
Mtb PNPase Rv2783c Mutant L328F
E. coli 70S-TEC complex in delivery state
SM: PHE
70S ribosome with doublet-decoding tRNASer3 bound to A-site GCA codon
SM: SPM
70S ribosome with cognate tRNASer3 bound to A-site AGC codon
Structure of the Arabidopsis thaliana 80S ribosome in complex with P- and E-site tRNAs and mRNA
SM: EPE TER
Assembly intermediate of human mitochondrial ribosome small subunit in complex with PUS1, METTL15 and RBFA(IN conformation) (state M1)
SM: NAD SPM
Structure of the Arabidopsis thaliana 80S ribosome in complex with P- and E-site tRNAs, mRNA, and thermospermine
SM: EPE TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER TER
Complex 5 30S-GE81112
Human 80S ribosome bound to IDB-002 stalled on FPAK-containing nascent chain
SM: A1B76
Cryo-EM structure of the Vibrio natrigens 30S ribosomal subunit in complex with spectinomycin.
SM: SCM
Complex 1 30S-IF1-IF2-IF3-GE81112
Complex 2 (BODY) 30S-IF1-IF3-tRNA-GE81112
Complex 3 (BODY) 30S-tRNA-GE81112
Complex 4 (BODY) 30S-GE81112 (weak residual tRNA)
Mouse mitoribosome large subunit assembly intermediate bound to NSUN4, METRF4, MRM2, GTPBP7 and MALSU1-L0R8F8-mt-ACP complex, State D (SAMC knock-out)
SM: SAH
Structure of the Arabidopsis thaliana 80S ribosome OVAC mutant in complex with P- and E-site tRNAs, mRNA, and thermospermine
CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH P/E-site tRNA AND mRNA : LM14Cs1H3 sKO STRAIN
SM: A1IWA
Structure of the Arabidopsis thaliana 80S ribosome OVAC mutant in complex with P- and E-site tRNAs and mRNA
CRYO-EM STRUCTURE OF HCT15 POLYSOMES IN HYBRID-PRE STATE
SM: HYG
High resolution structure of the thermophilic 60S ribosomal subunit of Chaetomium thermophilum
SM: SPM SPM
In situ HHT and CHX treated human P-Z state 80S ribosome
SM: 3HE HMT SPM SPM SPM SPM SPM SPM SPM
50S subunit of P. gingivalis ribosome with Lefamulin
SM: 62B
Structure of the wild-type Staphylococcus aureus 70S ribosome complexed with clincelin
SM: A1I09
Structure of the A2058-dimethylated Staphylococcus aureus 70S ribosome complexed with clincelin
The crystal structure of human m5C methyltransferase NSUN6 bound to its S-adenosyl-L-methionine analog and a NECTIN-2 3'-UTR RNA substrate
SM: SFG SFG
Crystal structure of B. subtilis CspR complexed with sinefungin and cellularly expressed tRNA Leu
SM: SFG
EF-G2 bound 70S ribosome complex of M. smegmatis
Cryo-EM structure of the thermophile spliceosome (state B*Q1)
SM: M7M
Cryo-EM structure of the thermophile spliceosome (state B*Q2)
Structural insights into the polymerase catalyzed FAD-capping of hepatitis C viral RNA
SM: CDP FAD
SM: FAD GDP
SM: C5P FAD
SM: GDP
Structure of arbekacin bound Escherichia coli 70S ribosome
SM: 84G 84G
Human 80S ribosome bound to small molecule SW393071
SM: A1BNL B3P
RlmR 23S rRNA methyltransferase from Thermus thermophilus in complex with methylated rRNA (Um2552) and S-adenosyl-L-homocysteine (SAH)
Impacts of ribosomal RNA sequence variation on gene expression and phenotype: Cryo-EM structure of the rrsB ribosome (BBB-70S)
SM: ATP ATP
Impacts of ribosomal RNA sequence variation on gene expression and phenotype: Cryo-EM structure of the rrsH ribosome (HBB-70S)
Mycobacterium smegmatis 70S ribosome with small molecule drug MK-7762
SM: A1BWO
Structure of WT E.coli ribosome 70S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site (S)-betahydroxyBocK charged NH-tRNAPyl
SM: PAR SPM
Structure of WT E.coli ribosome 70S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site (R) beta-2-hydroxy-BocLysine acid charged NH-tRNAPyl
Current selection range: to
Filter entries " Experimental resolution " between the two values. Global DB range: 0.6 – 11.2
Filter entries " Molecular weight (compound) " between the two values. Global DB range: 150 – 1000
Filter entries " Deposition date " between the two values. Global DB range: 1986 – 2027
Filter entries " Molecular weight (complex) " between the two values. Global DB range: 0 – 13090
Filter entries " Number of atoms " between the two values. Global DB range: 5 – 70
Filter entries " Number of interacting chains " between the two values. Global DB range: 1 – 4
Filter entries " Pocket size " between the two values. Global DB range: 15.9 – 394.0
Filter entries " SiteScore " between the two values. Global DB range: 0.3 – 1.3
Filter entries " Dscore " between the two values. Global DB range: -0.1 – 1.4
Filter entries " Exposure " between the two values. Global DB range: 0.1 – 1.0
Filter entries " Enclosure " between the two values. Global DB range: 0.3 – 1.0
Filter entries " Hydrophobicity " between the two values. Global DB range: 0.0 – 3.1
Filter entries " Hydrophilicity " between the two values. Global DB range: 0.2 – 2.8
Filter entries " Donor/Acceptor " between the two values. Global DB range: 0.0 – 5.0
Filter entries " Volume " between the two values. Global DB range: 21.2 – 1528.8