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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ljt

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.46
System mass 64.10 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 9ljt
Reference Wang De-Ping, Zhao Rong, Hu Wen-Shu, Li Hai-Ning, Cao Ji-Min, Zhou Xin, Xiang Ye. 2025. Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA Nature Communications
Equivalence Class NR_all_86876.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CDP
Residue . / 601
Chain C / A
Non-redundant False
Interacting RNA chains B/T
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains B/T: synthetic construct
RNA family global synthetic construct
Volume 539.20 Å3
Hydrophobicity 0.317
Hydrophilicity 1.398
Buriedness 0.779
Don/acc character 0.381
SiteScore 1.054
D Score 0.952
Kd

Compound FAD
Residue . / 601
Chain F / T
Non-redundant False
Interacting RNA chains B/T
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains B/T: synthetic construct
RNA family global synthetic construct
Volume 211.29 Å3
Hydrophobicity 0.854
Hydrophilicity 0.743
Buriedness 0.763
Don/acc character 0.358
SiteScore 0.749
D Score 0.704
Kd