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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9i1w

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.38
System mass 2037.19 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Thermochaetoides
RCSB PDB Entry 9i1w
Reference Wild Klemens, Klein Marius, Burkard Alicia, Marchand Virginie, Kellner Nikola, Paez Antonio, Pastore Stefan, Butto Tamer, Motorin Yuri, Helm Mark, Sinning Irmgard. 2025. Pseudouridine increases ribosome stability in a thermophilic eukaryote Nucleic Acids Research
Equivalence Class NR_all_93493.10
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 3403
Chain BB / 1
Non-redundant True
Interacting RNA chains A/1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/1: rRNA
RNA family global rRNA
Volume 616.71 Å3
Hydrophobicity 0.147
Hydrophilicity 1.646
Buriedness 0.879
Don/acc character 0.982
SiteScore 1.121
D Score 0.931
Kd

Compound SPM
Residue . / 3404
Chain CB / 1
Non-redundant True
Interacting RNA chains C/4, A/1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/1: rRNA, C/4: rRNA
RNA family global rRNA
Volume 439.38 Å3
Hydrophobicity 0.200
Hydrophilicity 1.093
Buriedness 0.618
Don/acc character 1.080
SiteScore 1.097
D Score 0.955
Kd