Complex 9l5r
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 2.80 |
| System mass | 2384.31 kDa |
| Deposition year | 2024 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermochaetoides |
| RCSB PDB Entry | 9l5r |
| Reference | Li Yi, Fischer Paulina, Wang Mengjiao, Zhou Qianxing, Song Aixia, Yuan Rui, Meng Wanyu, Chen Fei Xavier, Lührmann Reinhard, Lau Benjamin, Hurt Ed, Cheng Jingdong. 2025. Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates Cell Research |
| Equivalence Class |
NR_all_86252.2
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | M7M |
| Residue | . / 401 |
| Chain | XA / B |
| Non-redundant | True |
| Interacting RNA chains | A/2 |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | A/2: snRNA |
| RNA family global | snRNA |
| Volume | 632.49 Å3 |
| Hydrophobicity | 1.529 |
| Hydrophilicity | 0.708 |
| Buriedness | 0.752 |
| Don/acc character | 0.992 |
| SiteScore | 1.100 |
| D Score | 1.160 |
| Kd | — |