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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9h90

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.80
System mass 735.54 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Vibrio
RCSB PDB Entry 9h90
Reference Raulf Karoline, Koller Timm O, Beckert Bertrand, Lepak Alexander, Morici Martino, Mardirossian Mario, Scocchi Marco, Bange Gert, Wilson Daniel N. 2025. The structure of the Vibrio natriegens 70S ribosome in complex with the proline-rich antimicrobial peptide Bac5(1–17) Nucleic Acids Research
Equivalence Class NR_all_97544.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SCM
Residue . / 1601
Chain S / a
Non-redundant True
Interacting RNA chains J/a
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains J/a: rRNA
RNA family global rRNA
Volume 656.85 Å3
Hydrophobicity 0.081
Hydrophilicity 1.532
Buriedness 0.801
Don/acc character 1.138
SiteScore 1.219
D Score 0.921
Kd