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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9fqz

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.85
System mass 4049.20 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9fqz
Equivalence Class NR_all_46995.72, NR_all_65061.63, NR_all_69011.5
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 5109
Chain TG / L5
Non-redundant True
Interacting RNA chains CC/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains CC/L5: rRNA
RNA family global rRNA
Volume 299.44 Å3
Hydrophobicity 0.489
Hydrophilicity 0.968
Buriedness 0.648
Don/acc character 1.067
SiteScore 0.959
D Score 0.985
Kd

Compound ANM
Residue . / 5388
Chain MR / L5
Non-redundant True
Interacting RNA chains CC/L5
RNA environment detailled ion
RNA environment global RNA
RNA family chains CC/L5: rRNA
RNA family global rRNA
Volume 550.52 Å3
Hydrophobicity 0.512
Hydrophilicity 1.102
Buriedness 0.768
Don/acc character 1.540
SiteScore 1.197
D Score 1.042
Kd

Compound GDP
Residue . / 901
Chain GC / CB
Non-redundant True
Interacting RNA chains CC/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains CC/L5: rRNA
RNA family global rRNA
Volume 518.96 Å3
Hydrophobicity 0.136
Hydrophilicity 1.398
Buriedness 0.735
Don/acc character 0.490
SiteScore 1.025
D Score 0.926
Kd

Compound HYG
Residue . / 1979
Chain EG / S2
Non-redundant True
Interacting RNA chains UA/S2
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains UA/S2: rRNA
RNA family global rRNA
Volume 202.37 Å3
Hydrophobicity 0.000
Hydrophilicity 1.302
Buriedness 0.660
Don/acc character 1.992
SiteScore 0.711
D Score 0.573
Kd