HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound GTP

Identifiers

  • Canonical SMILES: 
    NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
  • IUPAC name: 
    guanosine 5'-(tetrahydrogen triphosphate)
  • InChi: 
    InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
  • InChiKey: 
    XKMLYUALXHKNFT-UUOKFMHZSA-N
  • SMARTS: 
    [#7]-[#6]1:[#7]:[#6]2:[#7](:[#6]:[#7]:[#6]:2:[#6](=[#8]):[#7]:1)-[#6@@H]1-[#8]-[#6@H](-[#6]-[#8]-[#15](-[#8])(=[#8])-[#8]-[#15](-[#8])(=[#8])-[#8]-[#15](-[#8])(-[#8])=[#8])-[#6@@H](-[#8])-[#6@H]-1-[#8]

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

5280317 CHEMBL1233147 DB04137

RNA-SM complexes

PDB code Deposition date Reference publication
9hrd Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
6cb3 Feb. 1, 2018 Bachas Sharrol T., Ferré-D'Amaré Adrian R.. . Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators Cell Chemical Biology
9k3v Oct. 20, 2024 Wang Qianmin, Ren Yulei, Jin Qianwei, Chen Xizi, Xu Yanhui. . Structural insights into human Pol III transcription initiation in action Nature
9k3u Oct. 20, 2024 Wang Qianmin, Ren Yulei, Jin Qianwei, Chen Xizi, Xu Yanhui. . Structural insights into human Pol III transcription initiation in action Nature
8pvk July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
7y7q June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
7oav April 20, 2021 Mieczkowski Mateusz, Steinmetzger Christian, Bessi Irene, Lenz Ann-Kathrin, Schmiedel Alexander, Holzapfel Marco, Lambert Christoph, Pena Vladimir, Höbartner Claudia. . Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine Nature Communications
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
7yc8 July 1, 2022 Zhang Xiaojing, Li Shanshan, Pintilie Grigore, Palo Michael Z, Zhang Kaiming. . Snapshots of the first-step self-splicing ofTetrahymenaribozyme revealed by cryo-EM Nucleic Acids Research
9lxo Feb. 18, 2025 Wang Qianmin, Ren Yulei, Jin Qianwei, Chen Xizi, Xu Yanhui. . Structural insights into human Pol III transcription initiation in action Nature
8fl4 Dec. 21, 2022 Vanden Broeck Arnaud, Klinge Sebastian. . Principles of human pre-60 S biogenesis Science
8fl2 Dec. 21, 2022 Vanden Broeck Arnaud, Klinge Sebastian. . Principles of human pre-60 S biogenesis Science
9hrf Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
9hrg Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
7of3 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
6oy5 May 14, 2019 Shin Yeonoh, Hedglin Mark, Murakami Katsuhiko S. . Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase Nucleic Acids Research
9hrg Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
7d7w Oct. 6, 2020 Chen Hao, Egger Michaela, Xu Xiaochen, Flemmich Laurin, Krasheninina Olga, Sun Aiai, Micura Ronald, Ren Aiming. . Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding Nucleic Acids Research
8pv2 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
9hrd Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
6uu2 Oct. 30, 2019 Zuo Yuhong, De Swastik, Feng Yingang, Steitz Thomas A.. . Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation iScience
29rf March 31, 2026 Yi Gangshun, Li Qingrong, Holmberg Hannah, Li Shisheng, Clare Daniel K., Wang Dong, Zhang Peijun. . Structural Dynamics of RNA Polymerase II During Nucleotide Addition Cycle []
7of4 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
7n2v May 29, 2021 Rundlet Emily J., Holm Mikael, Schacherl Magdalena, Natchiar S. Kundhavai, Altman Roger B., Spahn Christian M. T., Myasnikov Alexander G., Blanchard Scott C.. . Structural basis of early translocation events on the ribosome Nature
6ylh April 7, 2020 Kater Lukas, Mitterer Valentin, Thoms Matthias, Cheng Jingdong, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis Molecular Cell
4y1m Feb. 8, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
10mi Jan. 27, 2026 Dhingra Yukti, Landick Robert, Campbell Elizabeth A., Darst Seth A.. . RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle Proceedings of the National Academy of Sciences
7uoo April 13, 2022 Sekulski Kamil, Cruz Victor Emmanuel, Weirich Christine S., Erzberger Jan P.. . rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly Nature Communications
7uob April 12, 2022 Malone Brandon F., Perry Jason K., Olinares Paul Dominic B., Lee Hery W., Chen James, Appleby Todd C., Feng Joy Y., Bilello John P., Ng Honkit, Sotiris Johanna, Ebrahim Mark, Chua Eugene Y. D., Mendez Joshua H., Eng Ed T., Landick Robert, Götte Matthias, Chait Brian T., Campbell Elizabeth A., Darst Seth A.. . Structural basis for substrate selection by the SARS-CoV-2 replicase Nature
10mk Jan. 27, 2026 Dhingra Yukti, Landick Robert, Campbell Elizabeth A., Darst Seth A.. . RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle Proceedings of the National Academy of Sciences
6ft6 Feb. 20, 2018 Schuller Jan Michael, Falk Sebastian, Fromm Lisa, Hurt Ed, Conti Elena. . Structure of the nuclear exosome captured on a maturing preribosome Science
9gzn Oct. 4, 2024 Shen Jiayu, Goovaerts Quinten, Ajjugal Yogeeshwar, De Wijngaert Brent, Das Kalyan, Patel Smita S.. . Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism Molecular Cell
8pv5 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
7btb April 1, 2020 Wilson Daniel M., Li Yu, LaPeruta Amber, Gamalinda Michael, Gao Ning, Woolford John L.. . Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel Nature Communications
9r96 May 19, 2025 Shen Jiayu, Goovaerts Quinten, Ajjugal Yogeeshwar, De Wijngaert Brent, Das Kalyan, Patel Smita S.. . Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism Molecular Cell
9hrg Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
4y1m Feb. 8, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
4y1j Feb. 7, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
3ja1 March 30, 2015 Li Wen, Liu Zheng, Koripella Ravi Kiran, Langlois Robert, Sanyal Suparna, Frank Joachim. . Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G Science Advances
6uu0 Oct. 30, 2019 Zuo Yuhong, De Swastik, Feng Yingang, Steitz Thomas A.. . Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation iScience
8cf5 Feb. 2, 2023 Milicevic Nemanja, Jenner Lasse, Myasnikov Alexander, Yusupov Marat, Yusupova Gulnara. . mRNA reading frame maintenance during eukaryotic ribosome translocation Nature
7ycg July 1, 2022 Zhang Xiaojing, Li Shanshan, Pintilie Grigore, Palo Michael Z, Zhang Kaiming. . Snapshots of the first-step self-splicing ofTetrahymenaribozyme revealed by cryo-EM Nucleic Acids Research
9f37 April 25, 2024 Drncova Petra, Krischuns Tim, Naffakh Nadia, Cusack Stephen. . High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit []
7y7r June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
7oaw April 20, 2021 Mieczkowski Mateusz, Steinmetzger Christian, Bessi Irene, Lenz Ann-Kathrin, Schmiedel Alexander, Holzapfel Marco, Lambert Christoph, Pena Vladimir, Höbartner Claudia. . Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine Nature Communications
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
7of2 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
9hrg Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
6uu4 Oct. 30, 2019 Zuo Yuhong, De Swastik, Feng Yingang, Steitz Thomas A.. . Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation iScience
2e2h Nov. 14, 2006 Wang Dong, Bushnell David A., Westover Kenneth D., Kaplan Craig D., Kornberg Roger D.. . Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis Cell
8fl3 Dec. 21, 2022 Vanden Broeck Arnaud, Klinge Sebastian. . Principles of human pre-60 S biogenesis Science
7bt6 March 31, 2020 Wilson Daniel M., Li Yu, LaPeruta Amber, Gamalinda Michael, Gao Ning, Woolford John L.. . Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel Nature Communications
8pv7 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
7ych July 1, 2022 Zhang Xiaojing, Li Shanshan, Pintilie Grigore, Palo Michael Z, Zhang Kaiming. . Snapshots of the first-step self-splicing ofTetrahymenaribozyme revealed by cryo-EM Nucleic Acids Research
7y7t June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
9hrd Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
7of6 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
7of6 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
7d7y Oct. 6, 2020 Chen Hao, Egger Michaela, Xu Xiaochen, Flemmich Laurin, Krasheninina Olga, Sun Aiai, Micura Ronald, Ren Aiming. . Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding Nucleic Acids Research
7of2 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
3jct March 9, 2016 Wu Shan, Tutuncuoglu Beril, Yan Kaige, Brown Hailey, Zhang Yixiao, Tan Dan, Gamalinda Michael, Yuan Yi, Li Zhifei, Jakovljevic Jelena, Ma Chengying, Lei Jianlin, Dong Meng-Qiu, Woolford John L., Gao Ning. . Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes Nature
6ck4 Feb. 27, 2018 Knappenberger Andrew John, Reiss Caroline Wetherington, Strobel Scott A. . Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA eLife
8pv4 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
7of4 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
7elp April 12, 2021 Xu Xiaochen, Egger Michaela, Chen Hao, Bartosik Karolina, Micura Ronald, Ren Aiming. . Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition Nucleic Acids Research
8pv1 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
7d7z Oct. 6, 2020 Chen Hao, Egger Michaela, Xu Xiaochen, Flemmich Laurin, Krasheninina Olga, Sun Aiai, Micura Ronald, Ren Aiming. . Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding Nucleic Acids Research
5lwj Sept. 17, 2016 Wolter Antje C., Weickhmann A. Katharina, Nasiri Amir H., Hantke Katharina, Ohlenschläger Oliver, Wunderlich Christoph H., Kreutz Christoph, Duchardt‐Ferner Elke, Wöhnert Jens. . A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP‐Binding RNA Aptamer Angewandte Chemie International Edition
6cc1 Feb. 5, 2018 Bachas Sharrol T., Ferré-D'Amaré Adrian R.. . Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators Cell Chemical Biology
6lau Nov. 13, 2019 Sun Aiai, Gasser Catherina, Li Fudong, Chen Hao, Mair Stefan, Krasheninina Olga, Micura Ronald, Ren Aiming. . SAM-VI riboswitch structure and signature for ligand discrimination Nature Communications
9k38 Oct. 18, 2024 Wang Qianmin, Ren Yulei, Jin Qianwei, Chen Xizi, Xu Yanhui. . Structural insights into human Pol III transcription initiation in action Nature
4y1j Feb. 7, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
9hrd Dec. 18, 2024 Stafflinger Helena, Neißner Konstantin, Bartsch Saskia, Pichler Alexander K, Bartosik Karolina, Dhamotharan Karthikeyan, Abele Rupert, Duchardt-Ferner Elke, Micura Ronald, Schindelin Hermann, Wöhnert Jens. . Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Nucleic Acids Research
4y1i Feb. 7, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
8pvl July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
8cku Feb. 16, 2023 Milicevic Nemanja, Jenner Lasse, Myasnikov Alexander, Yusupov Marat, Yusupova Gulnara. . mRNA reading frame maintenance during eukaryotic ribosome translocation Nature
7y7q June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
6oy6 May 14, 2019 Shin Yeonoh, Hedglin Mark, Murakami Katsuhiko S. . Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase Nucleic Acids Research
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
7of5 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
6cc3 Feb. 5, 2018 Bachas Sharrol T., Ferré-D'Amaré Adrian R.. . Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators Cell Chemical Biology
9k39 Oct. 18, 2024 Wang Qianmin, Ren Yulei, Jin Qianwei, Chen Xizi, Xu Yanhui. . Structural insights into human Pol III transcription initiation in action Nature
9gzm Oct. 4, 2024 Shen Jiayu, Goovaerts Quinten, Ajjugal Yogeeshwar, De Wijngaert Brent, Das Kalyan, Patel Smita S.. . Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism Molecular Cell
7d7v Oct. 6, 2020 Chen Hao, Egger Michaela, Xu Xiaochen, Flemmich Laurin, Krasheninina Olga, Sun Aiai, Micura Ronald, Ren Aiming. . Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding Nucleic Acids Research
10ml Jan. 27, 2026 Dhingra Yukti, Landick Robert, Campbell Elizabeth A., Darst Seth A.. . RNA polymerase inhibitors reveal active-site motions essential for the nucleotide addition cycle Proceedings of the National Academy of Sciences
7d7x Oct. 6, 2020 Chen Hao, Egger Michaela, Xu Xiaochen, Flemmich Laurin, Krasheninina Olga, Sun Aiai, Micura Ronald, Ren Aiming. . Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding Nucleic Acids Research
6dta June 15, 2018 Molodtsov Vadim, Murakami Katsuhiko S.. . Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II Journal of Biological Chemistry
3s1r May 16, 2011 Liu Xin, Bushnell David A., Silva Daniel-Adriano, Huang Xuhui, Kornberg Roger D.. . Initiation Complex Structure and Promoter Proofreading Science
2au4 Aug. 26, 2005 CAROTHERS JAMES M., DAVIS JONATHAN H., CHOU JAMES J., SZOSTAK JACK W.. . Solution structure of an informationally complex high-affinity RNA aptamer to GTP RNA
9ey1 April 9, 2024 Valentín Gesé Genís, Hällberg B Martin. . Structural basis of 3′-tRNA maturation by the human mitochondrial RNase Z complex The EMBO Journal
7y7r June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
7of3 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
6cc1 Feb. 5, 2018 Bachas Sharrol T., Ferré-D'Amaré Adrian R.. . Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators Cell Chemical Biology
7yci July 1, 2022 Zhang Xiaojing, Li Shanshan, Pintilie Grigore, Palo Michael Z, Zhang Kaiming. . Snapshots of the first-step self-splicing ofTetrahymenaribozyme revealed by cryo-EM Nucleic Acids Research
6cb3 Feb. 1, 2018 Bachas Sharrol T., Ferré-D'Amaré Adrian R.. . Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators Cell Chemical Biology
5wfs July 12, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
4fwt July 2, 2012 Takeshita Daijiro, Yamashita Seisuke, Tomita Kozo. . Mechanism for Template-Independent Terminal Adenylation Activity of Qβ Replicase Structure
7of5 May 4, 2021 Hillen Hauke S., Lavdovskaia Elena, Nadler Franziska, Hanitsch Elisa, Linden Andreas, Bohnsack Katherine E., Urlaub Henning, Richter-Dennerlein Ricarda. . Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling Nature Communications
7oaw April 20, 2021 Mieczkowski Mateusz, Steinmetzger Christian, Bessi Irene, Lenz Ann-Kathrin, Schmiedel Alexander, Holzapfel Marco, Lambert Christoph, Pena Vladimir, Höbartner Claudia. . Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine Nature Communications
3j9z March 27, 2015 Li Wen, Liu Zheng, Koripella Ravi Kiran, Langlois Robert, Sanyal Suparna, Frank Joachim. . Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G Science Advances
8pv3 July 17, 2023 Thoms Matthias, Lau Benjamin, Cheng Jingdong, Fromm Lisa, Denk Timo, Kellner Nikola, Flemming Dirk, Fischer Paulina, Falquet Laurent, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation The EMBO Reports
4y1i Feb. 7, 2015 Price Ian R., Gaballa Ahmed, Ding Fang, Helmann John D., Ke Ailong. . Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches Molecular Cell
7y7q June 22, 2022 Cui Ruixue, Li Hao, Zhao Jin, Li Xuhang, Gan Jianhua, Ma Jinbiao. . Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1 Nucleic Acids Research
1uvn Jan. 21, 2004 Salgado Paula S., Makeyev Eugene V., Butcher Sarah J., Bamford Dennis H., Stuart David I., Grimes Jonathan M.. . The Structural Basis for RNA Specificity and Ca2+ Inhibition of an RNA-Dependent RNA Polymerase Structure
7po6 Sept. 8, 2021 Jones Alisha N, Tikhaia Ekaterina, Mourão André, Sattler Michael. . Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1 Nucleic Acids Research
6ylg April 7, 2020 Kater Lukas, Mitterer Valentin, Thoms Matthias, Cheng Jingdong, Berninghausen Otto, Beckmann Roland, Hurt Ed. . Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis Molecular Cell

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 522.99 g/mol
HBA 13
HBD 8
HBA + HBD
AlogP -2.34
TPSA 299.10
RB 8

Radar chart