HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound PHE

Identifiers

  • Canonical SMILES: 
    N[C@@H](Cc1ccccc1)C(O)=O
  • IUPAC name: 
    L-phenylalanine
  • InChi: 
    InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
  • InChiKey: 
    COLNVLDHVKWLRT-QMMMGPOBSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

6140 CHEMBL301523 DB00120

RNA-SM complexes

PDB code Deposition date Reference publication
3cma March 21, 2008 Simonović Miljan, Steitz Thomas A.. . Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3′-hydroxyl group of A76 of the unacylated A-site tRNA RNA
3cme March 21, 2008 Simonović Miljan, Steitz Thomas A.. . Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3′-hydroxyl group of A76 of the unacylated A-site tRNA RNA
5o61 June 3, 2017 Hentschel Jendrik, Burnside Chloe, Mignot Ingrid, Leibundgut Marc, Boehringer Daniel, Ban Nenad. . The Complete Structure of the Mycobacterium smegmatis 70S Ribosome Cell Reports
5tgm Sept. 28, 2016 Melnikov Sergey, Mailliot Justine, Rigger Lukas, Neuner Sandro, Shin Byung‐Sik, Yusupova Gulnara, Dever Thomas E, Micura Ronald, Yusupov Marat. . Molecular insights into protein synthesis with proline residues The EMBO Reports
5tgm Sept. 28, 2016 Melnikov Sergey, Mailliot Justine, Rigger Lukas, Neuner Sandro, Shin Byung‐Sik, Yusupova Gulnara, Dever Thomas E, Micura Ronald, Yusupov Marat. . Molecular insights into protein synthesis with proline residues The EMBO Reports
5wdt July 6, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5we4 July 7, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5we6 July 7, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wf0 July 11, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wfk July 12, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wfs July 12, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
9gr1 Sept. 10, 2024 Webster Michael W., Chauvier Adrien, Rahil Huma, Graziadei Andrea, Charles Kristine, Miropolskaya Nataliya, Takacs Maria, Saint-André Charlotte, Rappsilber Juri, Walter Nils G., Weixlbaumer Albert. . Molecular basis of mRNA delivery to the bacterial ribosome Science
9k0z Oct. 16, 2024 Baid Priya, Sengupta Jayati. . Cryo‐ EM structural analyses reveal a unique role for elongation factor G2 ( EF ‐ G2 ) in Mycobacteria The FEBS Journal

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 165.19 g/mol
HBA not available
HBD not available
HBA + HBD
AlogP not available
TPSA not available
RB not available

Radar chart