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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9gxx

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.61
System mass 2236.64 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 9gxx
Reference Krishnaswamy Shruthi, Akbar Shirin, Larsson Daniel S. D., Chen Yang, Selmer Maria. 2025. Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center Nature Communications
Equivalence Class NR_all_35542.167, NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 6193
Chain DM / a
Non-redundant True
Interacting RNA chains Z/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains Z/a: rRNA
RNA family global rRNA
Volume 390.68 Å3
Hydrophobicity 0.192
Hydrophilicity 1.163
Buriedness 0.769
Don/acc character 1.144
SiteScore 1.194
D Score 1.018
Kd