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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ljv

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.25
System mass 64.02 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 9ljv
Reference Wang De-Ping, Zhao Rong, Hu Wen-Shu, Li Hai-Ning, Cao Ji-Min, Zhou Xin, Xiang Ye. 2025. Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA Nature Communications
Equivalence Class NR_all_68723.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound C5P
Residue . / 601
Chain C / A
Non-redundant True
Interacting RNA chains B/B
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains B/B: synthetic construct
RNA family global synthetic construct
Volume 617.06 Å3
Hydrophobicity 0.349
Hydrophilicity 1.355
Buriedness 0.837
Don/acc character 0.418
SiteScore 1.093
D Score 1.000
Kd

Compound FAD
Residue . / 601
Chain F / B
Non-redundant False
Interacting RNA chains B/B
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains B/B: synthetic construct
RNA family global synthetic construct
Volume 508.33 Å3
Hydrophobicity 0.890
Hydrophilicity 0.788
Buriedness 0.752
Don/acc character 1.088
SiteScore 1.051
D Score 1.091
Kd