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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9gmo

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.59
System mass 2645.88 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9gmo
Reference Akers Jared, Bothe Adrian, Suh Hanna, Jung Carmen, Stolp Zachary, Ghosh Tanushree, Yan Liewei, Wang Yuming, Grismer Tarabryn, Reyes Andreas, Hu Tianyi, Xu Shouling, Ban Nenad, Kostova Kamena. 2024. ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates preprint (bioRxiv)
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound EPE
Residue . / 201
Chain BP / M
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 362.89 Å3
Hydrophobicity 0.356
Hydrophilicity 1.224
Buriedness 0.811
Don/acc character 0.539
SiteScore 0.730
D Score 0.585
Kd