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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9g5d

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 1215.89 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9g5d
Reference Heinrichs Marleen, Finke Anna Franziska, Aibara Shintaro, Krempler Angelique, Boshnakovska Angela, Rehling Peter, Hillen Hauke S., Richter-Dennerlein Ricarda. 2025. Coupling of ribosome biogenesis and translation initiation in human mitochondria Nature Communications
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1710
Chain QA / A
Non-redundant True
Interacting RNA chains E/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains E/A: rRNA
RNA family global rRNA
Volume 1153.51 Å3
Hydrophobicity 0.391
Hydrophilicity 1.161
Buriedness 0.854
Don/acc character 1.283
SiteScore 1.104
D Score 1.074
Kd