Harnessing RIBOnucleic acid - Small molecules Structures
Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe
SM: PAR
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe
SM: SPM
Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II)
Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III)
mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure)
SM: 3H3 ANM
Structure of the Cas7-11-Csx29-guide RNA-target RNA (non-matching PFS) complex
SM: C5P
SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP
SM: GNP
Crystal structure of NAD+ -II riboswitch in complex with NAD+
SM: NAD
Crystal structure of NAD+ -II riboswitch in complex with NMN
SM: NMN
Cryo-EM structure of the the NS5-NS3 RNA-elongation complex
SM: CDP
Crystal structure of MnmM from B. subtilis complexed with Gln-TTG anti-codon stem loop and SAM (2.90 A)
SM: SAM
Crystal structure of MnmM from S. aureus complexed with SAM and tRNA anti-codon stem loop (ASL) (1.55 A)
Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome
Dibekacin-bound E.coli 70S ribosome in the PURE system
SM: 84D SPM
Arbekacin-bound E.coli 70S ribosome in the PURE system
SM: 84G SPM
Dibekacin-added human 80S ribosome
SM: 84D
Arbekacin-added human 80S ribosome
SM: 84G
Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide
SM: 3HE
Wheat 80S ribosome pausing on AUG-Stop with cycloheximide
Crystal structure of RhoBAST complexed with TMR-DN
SM: V8C
Cryo-EM structure of the human 55S mitoribosome with Tigecycline
SM: T1C
Cryo-EM structure of the human 39S mitoribosome with Tigecycline
Cryo-EM structure of the human 80S ribosome with Tigecycline
Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A
SM: GDP T1C
Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM)
SM: 3K5 PAR
Structure of Candida albicans 80S ribosome in complex with mefloquine
SM: SPK YMZ
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol)
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM)
55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA
28S mammalian mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA
Monkeypox virus VP39 in complex with SAH and cap0
SM: SAH
Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state)
SM: 3K5 GET
Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) bound with pre-let7g miRNA and UTPalphaS
SM: P5E
E167K RF2 on E. coli 70S release complex with UGG (Structure I)
E167K RF2 on E. coli 70S release complex with UGG (Structure II)
E167K RF2 on E. coli 70S release complex with UGG (Structure III)
Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state
SM: WUX
Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state
Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state
SM: FUA
Ternary complex of translating ribosome, NAC and METAP1
80S yeast ribosome in complex with HaterumaimideQ
SM: X1K
Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells
SM: CLM SPM
Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit
80S yeast ribosome in complex with Fluorolissoclimide
SM: VDU
Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells
Yeast 60S ribosomal subunit, RPL39 deletion
Mouse RPL39 integrated into the yeast 60S ribosomal subunit
Yeast 60S ribosomal subunit
Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S)
SM: CLM
Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S)
80S yeast ribosome in complex with Methyllissoclimide
SM: XBI
Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state)
SM: ATP
Mouse RPL39L integrated into the yeast 60S ribosomal subunit
80S yeast ribosome in complex with Bromolissoclimide
SM: ZWB
Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A
SM: 2KH
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
SM: A0I
Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation)
Chaetomium thermophilum pre-60S State 6 - pre-5S rotation - L1 intermediate - composite structure
SM: GTP
Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1
Current selection range: to