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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8hl1

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.93
System mass 2575.89 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Sulfolobus
RCSB PDB Entry 8hl1
Reference Wang Ying-Hui, Dai Hong, Zhang Ling, Wu Yun, Wang Jingfen, Wang Chen, Xu Cai-Huang, Hou Hai, Yang Bing, Zhu Yongqun, Zhang Xing, Zhou Jie. 2023. Cryo-electron microscopy structure and translocation mechanism of the crenarchaeal ribosome Nucleic Acids Research
Equivalence Class NR_all_27894.7
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GNP
Residue . / 801
Chain UB / AEFG
Non-redundant True
Interacting RNA chains B/A23S
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains B/A23S: rRNA
RNA family global rRNA
Volume 253.82 Å3
Hydrophobicity 0.077
Hydrophilicity 1.851
Buriedness 0.794
Don/acc character 0.632
SiteScore 1.064
D Score 0.813
Kd