Complex 8g6j
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 2.80 |
| System mass | 4006.57 kDa |
| Deposition year | 2023 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 8g6j |
| Reference | Holm Mikael, Natchiar S. Kundhavai, Rundlet Emily J., Myasnikov Alexander G., Watson Zoe L., Altman Roger B., Wang Hao-Yuan, Taunton Jack, Blanchard Scott C.. 2023. mRNA decoding in human is kinetically and structurally distinct from bacteria Nature |
| Equivalence Class |
NR_all_65061.63,
NR_all_90476.6
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 3HE |
| Residue | . / 5117 |
| Chain | NG / L5 |
| Non-redundant | True |
| Interacting RNA chains | C/L5 |
| RNA environment detailled | protein, other |
| RNA environment global | RNA/Other |
| RNA family chains | C/L5: rRNA |
| RNA family global | rRNA |
| Volume | 292.92 Å3 |
| Hydrophobicity | 0.442 |
| Hydrophilicity | 0.965 |
| Buriedness | 0.659 |
| Don/acc character | 1.083 |
| SiteScore | 0.947 |
| D Score | 0.968 |
| Kd | — |
| Compound | GSP |
| Residue | . / 501 |
| Chain | RR / EF |
| Non-redundant | True |
| Interacting RNA chains | C/L5 |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | C/L5: rRNA |
| RNA family global | rRNA |
| Volume | 424.98 Å3 |
| Hydrophobicity | 0.118 |
| Hydrophilicity | 1.706 |
| Buriedness | 0.865 |
| Don/acc character | 0.662 |
| SiteScore | 1.111 |
| D Score | 0.903 |
| Kd | — |
| Compound | HMT |
| Residue | . / 5118 |
| Chain | OG / L5 |
| Non-redundant | True |
| Interacting RNA chains | C/L5, GC/Pt |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | C/L5: rRNA, GC/Pt: tRNA |
| RNA family global | multiple |
| Volume | 620.14 Å3 |
| Hydrophobicity | 0.561 |
| Hydrophilicity | 1.165 |
| Buriedness | 0.797 |
| Don/acc character | 1.124 |
| SiteScore | 1.066 |
| D Score | 1.039 |
| Kd | — |