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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8h1b

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 1.55
System mass 55.51 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Staphylococcus
RCSB PDB Entry 8h1b
Reference Cho Gyuhyeok, Lee Jangmin, Kim Jungwook. 2023. Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification Nucleic Acids Research
Equivalence Class NR_all_21822.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SAM
Residue . / 201
Chain E / A
Non-redundant True
Interacting RNA chains C/C
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/C: tRNA
RNA family global tRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SAM
Residue . / 201
Chain F / B
Non-redundant False
Interacting RNA chains D/D
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/D: tRNA
RNA family global tRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd