Complex 8opp
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.76 |
| System mass | 180.00 kDa |
| Deposition year | 2023 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 8opp |
| Reference | Yi Gangshun, Ye Mingda, Carrique Loic, El-Sagheer Afaf, Brown Tom, Norbury Chris J., Zhang Peijun, Gilbert Robert J. C.. 2024. Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs Nature Structural & Molecular Biology |
| Equivalence Class |
NR_all_11158.1
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | P5E |
| Residue | . / 1501 |
| Chain | C / A |
| Non-redundant | True |
| Interacting RNA chains | B/D |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | B/D: unknown |
| RNA family global | unknown |
| Volume | 646.90 Å3 |
| Hydrophobicity | 0.771 |
| Hydrophilicity | 1.341 |
| Buriedness | 0.880 |
| Don/acc character | 0.587 |
| SiteScore | 1.122 |
| D Score | 1.031 |
| Kd | — |