Harnessing RIBOnucleic acid - Small molecules Structures
Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA
SM: DOL
Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA
Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA
Cryo-EM structure of a late human pre-40S ribosomal subunit - State G
SM: ATP
Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1
Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2
50S Deinococcus radiodurans ribosome bounded with mycinamicin I
SM: QTZ
SM: QU2
50S Deinococcus radiodurans ribosome bounded with mycinamicin IV
SM: MIV
Structure of the human mitoribosome in the post translocation state bound to mtEF-G1
SM: GCP
Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
SM: GE6
Human pre-Bact-1 spliceosome core structure
SM: IHP
Human pre-Bact-2 spliceosome
mt-SSU from Trypanosoma cruzi in complex with mt-IF-3.
SM: UTP
Context-specific inhibition of eukaryotic translation by macrolide antibiotics
SM: TEL
E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.
SM: ERY SY5
Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.12 Angstroms resolution(state R1)
SM: GTP
Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.22 Angstroms resolution(state R2)
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.
Crystal structure of the Cas12i1 R-loop complex before target DNA cleavage
SM: CIT
Crystal structure of the Cas12i1 R-loop complex after target DNA cleavage
Crystal structure of the Cas12i1-crRNA binary complex
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
SM: AT9
Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage
Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin
SM: CTY
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM).
SM: SAM
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).
SM: SAH
Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II)
Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS)
Preaminoacylation complex of M. tuberculosis PheRS with cognate precursor tRNA and 5'-O-(N-phenylalanyl)sulfamoyl-adenosine (F-AMS)
SM: W5Y
Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (crystal form I)
SM: EPE
Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (native, crystal form I)
Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution
SM: ARG YXM
80S rabbit ribosome stalled with benzamide-CHX
SM: Z2V
Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation
Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2)
SM: ATP FUA
Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation
Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1)
SM: ATP GTP SCM
Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation
Elongating 70S ribosome complex in a post-translocation (POST) conformation
Cycloheximide bound vacant 80S structure isolated from cbf5-D95A
SM: 3HE
State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model
State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model
55S mammalian mitochondrial ribosome with mtRF1a and P-site tRNAMet
SM: 5GP SPM
55S mammalian mitochondrial ribosome with ICT1 and P site tRNAMet
39S mammalian mitochondrial large ribosomal subunit with mtRRF (post) and mtEFG2
55S mammalian mitochondrial ribosome with mtRRF (pre) and tRNA(P/E)
55S mammalian mitochondrial ribosome with tRNA(P/P) and tRNA(E*)
Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA
SM: ERY
Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA
Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA
Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.
SM: BLS
Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S
Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan
SM: TRP
Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan
Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan
Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution)
SM: SPM
Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot)
Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with GTPBP6.
Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with MTERF4-NSUN4 (dataset2).
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