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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6ywx

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.10
System mass 4123.91 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Neurospora
RCSB PDB Entry 6ywx
Reference Itoh Yuzuru, Naschberger Andreas, Mortezaei Narges, Herrmann Johannes M., Amunts Alexey. 2020. Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi Nature Communications
Equivalence Class NR_all_72592.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 4301
Chain CJ / E
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 492.21 Å3
Hydrophobicity 0.385
Hydrophilicity 1.280
Buriedness 0.848
Don/acc character 0.795
SiteScore 1.086
D Score 1.013
Kd

Compound SPM
Residue . / 3651
Chain ZH / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 874.65 Å3
Hydrophobicity 0.178
Hydrophilicity 1.732
Buriedness 0.854
Don/acc character 0.836
SiteScore 1.104
D Score 0.888
Kd