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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6ytf

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 633.95 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Acinetobacter
RCSB PDB Entry 6ytf
Reference Nicholson David, Edwards Thomas A., O'Neill Alex J., Ranson Neil A.. 2020. Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics Structure
Equivalence Class NR_all_43481.6
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound T1C
Residue . / 1624
Chain HA / 3
Non-redundant True
Interacting RNA chains A/3
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/3: rRNA
RNA family global rRNA
Volume 338.20 Å3
Hydrophobicity 0.012
Hydrophilicity 1.185
Buriedness 0.767
Don/acc character 3.405
SiteScore 0.819
D Score 0.877
Kd