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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7nqh

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.50
System mass 3121.26 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Sus
RCSB PDB Entry 7nqh
Reference Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. 2021. Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
Equivalence Class NR_all_24610.5, NR_all_19551.9
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 5GP
Residue . / 1791
Chain BP / BA
Non-redundant True
Interacting RNA chains OC/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OC/BA: rRNA
RNA family global rRNA
Volume 349.86 Å3
Hydrophobicity 0.194
Hydrophilicity 1.125
Buriedness 0.672
Don/acc character 2.175
SiteScore 1.133
D Score 0.977
Kd

Compound 5GP
Residue . / 1792
Chain CP / BA
Non-redundant True
Interacting RNA chains OC/BA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OC/BA: rRNA
RNA family global rRNA
Volume 360.49 Å3
Hydrophobicity 0.274
Hydrophilicity 1.807
Buriedness 0.656
Don/acc character 0.368
SiteScore 1.122
D Score 0.744
Kd

Compound SPM
Residue . / 3001
Chain GD / AA
Non-redundant True
Interacting RNA chains AB/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains AB/AA: rRNA
RNA family global rRNA
Volume 757.34 Å3
Hydrophobicity 0.131
Hydrophilicity 1.377
Buriedness 0.760
Don/acc character 1.503
SiteScore 1.191
D Score 0.947
Kd

Compound SPM
Residue . / 1793
Chain DP / BA
Non-redundant True
Interacting RNA chains OC/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OC/BA: rRNA
RNA family global rRNA
Volume 648.27 Å3
Hydrophobicity 0.289
Hydrophilicity 1.194
Buriedness 0.809
Don/acc character 2.144
SiteScore 1.074
D Score 1.036
Kd

Compound SPM
Residue . / 1794
Chain EP / BA
Non-redundant True
Interacting RNA chains OC/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OC/BA: rRNA
RNA family global rRNA
Volume 533.02 Å3
Hydrophobicity 0.146
Hydrophilicity 1.133
Buriedness 0.746
Don/acc character 1.285
SiteScore 1.032
D Score 1.018
Kd