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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7aor

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.50
System mass 7881.46 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Trypanosoma
RCSB PDB Entry 7aor
Reference Soufari Heddy, Waltz Florent, Parrot Camila, Durrieu-Gaillard Stéphanie, Bochler Anthony, Kuhn Lauriane, Sissler Marie, Hashem Yaser. 2020. Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis Proceedings of the National Academy of Sciences
Equivalence Class NR_all_53658.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 401
Chain HB / aj
Non-redundant True
Interacting RNA chains DB/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains DB/A: rRNA
RNA family global rRNA
Volume 212.32 Å3
Hydrophobicity 0.011
Hydrophilicity 1.292
Buriedness 0.685
Don/acc character 0.360
SiteScore 0.893
D Score 0.804
Kd