Complex 7abf
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.90 |
| System mass | 1005.87 kDa |
| Deposition year | 2020 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 7abf |
| Reference | Townsend Cole, Leelaram Majety N., Agafonov Dmitry E., Dybkov Olexandr, Will Cindy L., Bertram Karl, Urlaub Henning, Kastner Berthold, Stark Holger, Lührmann Reinhard. 2020. Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation Science |
| Equivalence Class |
NR_all_73286.32
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | IHP |
| Residue | . / 3001 |
| Chain | P / A |
| Non-redundant | True |
| Interacting RNA chains | M/Z |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | M/Z: synthetic construct |
| RNA family global | synthetic construct |
| Volume | 634.21 Å3 |
| Hydrophobicity | 0.823 |
| Hydrophilicity | 1.137 |
| Buriedness | 0.811 |
| Don/acc character | 0.998 |
| SiteScore | 1.076 |
| D Score | 1.056 |
| Kd | — |