HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7nql

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.40
System mass 3100.50 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Sus
RCSB PDB Entry 7nql
Reference Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. 2021. Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
Equivalence Class NR_all_24610.5, NR_all_19551.9
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 5GP
Residue . / 3211
Chain SK / BA
Non-redundant True
Interacting RNA chains D/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/BA: rRNA
RNA family global rRNA
Volume 361.52 Å3
Hydrophobicity 0.204
Hydrophilicity 0.998
Buriedness 0.656
Don/acc character 2.316
SiteScore 1.130
D Score 1.008
Kd

Compound 5GP
Residue . / 3212
Chain TK / BA
Non-redundant True
Interacting RNA chains D/BA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains D/BA: rRNA
RNA family global rRNA
Volume 275.77 Å3
Hydrophobicity 0.234
Hydrophilicity 1.805
Buriedness 0.651
Don/acc character 0.551
SiteScore 1.119
D Score 0.743
Kd

Compound SPM
Residue . / 3213
Chain UK / BA
Non-redundant True
Interacting RNA chains D/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/BA: rRNA
RNA family global rRNA
Volume 646.56 Å3
Hydrophobicity 0.236
Hydrophilicity 1.276
Buriedness 0.813
Don/acc character 1.702
SiteScore 1.077
D Score 1.012
Kd

Compound SPM
Residue . / 3214
Chain VK / BA
Non-redundant True
Interacting RNA chains D/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/BA: rRNA
RNA family global rRNA
Volume 555.32 Å3
Hydrophobicity 0.160
Hydrophilicity 1.195
Buriedness 0.736
Don/acc character 1.299
SiteScore 1.025
D Score 0.992
Kd

Compound SPM
Residue . / 3001
Chain NL / AA
Non-redundant True
Interacting RNA chains UA/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains UA/AA: rRNA
RNA family global rRNA
Volume 656.16 Å3
Hydrophobicity 0.135
Hydrophilicity 1.151
Buriedness 0.798
Don/acc character 2.713
SiteScore 1.217
D Score 1.044
Kd