HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7nsj

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.90
System mass 3097.03 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Sus
RCSB PDB Entry 7nsj
Reference Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. 2021. Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
Equivalence Class NR_all_24610.5, NR_all_19551.9
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 5GP
Residue . / 1791
Chain NO / BA
Non-redundant True
Interacting RNA chains AB/BA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains AB/BA: rRNA
RNA family global rRNA
Volume 380.39 Å3
Hydrophobicity 0.122
Hydrophilicity 1.870
Buriedness 0.647
Don/acc character 0.436
SiteScore 1.116
D Score 0.719
Kd

Compound SPM
Residue . / 3001
Chain FD / AA
Non-redundant True
Interacting RNA chains YA/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains YA/AA: rRNA
RNA family global rRNA
Volume 601.28 Å3
Hydrophobicity 0.190
Hydrophilicity 1.195
Buriedness 0.798
Don/acc character 2.402
SiteScore 1.217
D Score 1.029
Kd

Compound SPM
Residue . / 1792
Chain OO / BA
Non-redundant True
Interacting RNA chains AB/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains AB/BA: rRNA
RNA family global rRNA
Volume 622.20 Å3
Hydrophobicity 0.318
Hydrophilicity 1.206
Buriedness 0.803
Don/acc character 1.548
SiteScore 1.070
D Score 1.029
Kd

Compound SPM
Residue . / 1793
Chain PO / BA
Non-redundant True
Interacting RNA chains AB/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains AB/BA: rRNA
RNA family global rRNA
Volume 562.52 Å3
Hydrophobicity 0.193
Hydrophilicity 1.199
Buriedness 0.765
Don/acc character 0.886
SiteScore 1.045
D Score 1.008
Kd