Complex 7azy
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 2.88 |
| System mass | 1916.77 kDa |
| Deposition year | 2020 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Saccharomyces |
| RCSB PDB Entry | 7azy |
| Reference | Svetlov Maxim S., Koller Timm O., Meydan Sezen, Shankar Vaishnavi, Klepacki Dorota, Polacek Norbert, Guydosh Nicholas R., Vázquez-Laslop Nora, Wilson Daniel N., Mankin Alexander S.. 2021. Context-specific action of macrolide antibiotics on the eukaryotic ribosome Nature Communications |
| Equivalence Class |
NR_all_90506.85
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | TEL |
| Residue | . / 3401 |
| Chain | QA / E |
| Non-redundant | True |
| Interacting RNA chains | MA/E |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | MA/E: rRNA |
| RNA family global | rRNA |
| Volume | 733.68 Å3 |
| Hydrophobicity | 0.293 |
| Hydrophilicity | 1.056 |
| Buriedness | 0.768 |
| Don/acc character | 2.471 |
| SiteScore | 1.197 |
| D Score | 1.057 |
| Kd | — |