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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7n1p

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.33
System mass 2255.98 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7n1p
Reference Rundlet Emily J., Holm Mikael, Schacherl Magdalena, Natchiar S. Kundhavai, Altman Roger B., Spahn Christian M. T., Myasnikov Alexander G., Blanchard Scott C.. 2021. Structural basis of early translocation events on the ribosome Nature
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 3001
Chain VF / 23
Non-redundant True
Interacting RNA chains W/23
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains W/23: rRNA
RNA family global rRNA
Volume 71.34 Å3
Hydrophobicity 0.248
Hydrophilicity 0.922
Buriedness 0.501
Don/acc character 1.842
SiteScore 0.716
D Score 0.524
Kd

Compound ATP
Residue . / 3002
Chain WF / 23
Non-redundant True
Interacting RNA chains W/23
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains W/23: rRNA
RNA family global rRNA
Volume 30.87 Å3
Hydrophobicity 0.308
Hydrophilicity 1.055
Buriedness 0.573
Don/acc character 0.814
SiteScore 0.437
D Score 0.325
Kd

Compound ATP
Residue . / 3003
Chain XF / 23
Non-redundant True
Interacting RNA chains W/23
RNA environment detailled ion
RNA environment global RNA
RNA family chains W/23: rRNA
RNA family global rRNA
Volume 165.67 Å3
Hydrophobicity 0.358
Hydrophilicity 1.222
Buriedness 0.641
Don/acc character 1.738
SiteScore 1.001
D Score 0.784
Kd