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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7k55

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.30
System mass 2299.55 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7k55
Reference Demo Gabriel, Gamper Howard B., Loveland Anna B., Masuda Isao, Carbone Christine E., Svidritskiy Egor, Hou Ya-Ming, Korostelev Andrei A.. 2021. Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation Nature Communications
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GCP
Residue . / 801
Chain JB / 8
Non-redundant True
Interacting RNA chains BB/1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains BB/1: rRNA
RNA family global rRNA
Volume 663.02 Å3
Hydrophobicity 0.056
Hydrophilicity 1.911
Buriedness 0.795
Don/acc character 0.630
SiteScore 1.065
D Score 0.794
Kd