HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound 5GP

Identifiers

  • Canonical SMILES: 
    NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
  • IUPAC name: 
    5'-guanylic acid
  • InChi: 
    InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
  • InChiKey: 
    RQFCJASXJCIDSX-UUOKFMHZSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

5280325 CHEMBL283807 DB01972

RNA-SM complexes

PDB code Deposition date Reference publication
3slq June 24, 2011 Pikovskaya Olga, Polonskaia Anna, Patel Dinshaw J, Serganov Alexander. . Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch Nature Chemical Biology
3slq June 24, 2011 Pikovskaya Olga, Polonskaia Anna, Patel Dinshaw J, Serganov Alexander. . Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch Nature Chemical Biology
4x4n Dec. 3, 2014 Kuhn Claus-D., Wilusz Jeremy E., Zheng Yuxuan, Beal Peter A., Joshua-Tor Leemor. . On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme Cell
4x4v Dec. 3, 2014 Kuhn Claus-D., Wilusz Jeremy E., Zheng Yuxuan, Beal Peter A., Joshua-Tor Leemor. . On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme Cell
4x4v Dec. 3, 2014 Kuhn Claus-D., Wilusz Jeremy E., Zheng Yuxuan, Beal Peter A., Joshua-Tor Leemor. . On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme Cell
4x4v Dec. 3, 2014 Kuhn Claus-D., Wilusz Jeremy E., Zheng Yuxuan, Beal Peter A., Joshua-Tor Leemor. . On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme Cell
5dhb Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhb Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhb Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhb Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5dhc Aug. 30, 2015 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5l00 July 26, 2016 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5l00 July 26, 2016 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5l00 July 26, 2016 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
5l00 July 26, 2016 Zhang Wen, Tam Chun Pong, Wang Jiawei, Szostak Jack W.. . Unusual Base-Pairing Interactions in Monomer–Template Complexes ACS Central Science
6cab Jan. 29, 2018 Zhang Wen, Walton Travis, Li Li, Szostak Jack W. . Crystallographic observation of nonenzymatic RNA primer extension eLife
6cab Jan. 29, 2018 Zhang Wen, Walton Travis, Li Li, Szostak Jack W. . Crystallographic observation of nonenzymatic RNA primer extension eLife
6cab Jan. 29, 2018 Zhang Wen, Walton Travis, Li Li, Szostak Jack W. . Crystallographic observation of nonenzymatic RNA primer extension eLife
6cab Jan. 29, 2018 Zhang Wen, Walton Travis, Li Li, Szostak Jack W. . Crystallographic observation of nonenzymatic RNA primer extension eLife
6gaw April 13, 2018 Kummer Eva, Leibundgut Marc, Rackham Oliver, Lee Richard G., Boehringer Daniel, Filipovska Aleksandra, Ban Nenad. . Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM Nature
6gaw April 13, 2018 Kummer Eva, Leibundgut Marc, Rackham Oliver, Lee Richard G., Boehringer Daniel, Filipovska Aleksandra, Ban Nenad. . Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM Nature
6gb2 April 13, 2018 Kummer Eva, Leibundgut Marc, Rackham Oliver, Lee Richard G., Boehringer Daniel, Filipovska Aleksandra, Ban Nenad. . Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM Nature
6gb2 April 13, 2018 Kummer Eva, Leibundgut Marc, Rackham Oliver, Lee Richard G., Boehringer Daniel, Filipovska Aleksandra, Ban Nenad. . Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM Nature
6n5s Nov. 22, 2018
6ydp March 20, 2020 Kummer Eva, Ban Nenad. . Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1 The EMBO Journal
6ydp March 20, 2020 Kummer Eva, Ban Nenad. . Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1 The EMBO Journal
6ydw March 21, 2020 Kummer Eva, Ban Nenad. . Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1 The EMBO Journal
7nqh March 1, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nqh March 1, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nql March 1, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nql March 1, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nsh March 7, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nsh March 7, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nsi March 7, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7nsj March 7, 2021 Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. . Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
7tql Jan. 26, 2022 Lapointe Christopher P., Grosely Rosslyn, Sokabe Masaaki, Alvarado Carlos, Wang Jinfan, Montabana Elizabeth, Villa Nancy, Shin Byung-Sik, Dever Thomas E., Fraser Christopher S., Fernández Israel S., Puglisi Joseph D.. . eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining Nature
8sx6 May 19, 2023 Dantsu Yuliya, Zhang Ying, Zhang Wen. . Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand RSC Chemical Biology
8sx6 May 19, 2023 Dantsu Yuliya, Zhang Ying, Zhang Wen. . Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand RSC Chemical Biology
8vvq Jan. 31, 2024
9mqs Jan. 6, 2025 Liu Tianshuo, Xu Ling, Chung Kevin, Sisto Luke J., Hwang Jimin, Zhang Chengxin, Van Zandt Michael C., Pyle Anna Marie. . Molecular insights into de novo small-molecule recognition by an intron RNA structure Proceedings of the National Academy of Sciences

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 363.22 g/mol
HBA not available
HBD not available
HBA + HBD
AlogP not available
TPSA not available
RB not available

Radar chart