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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7n8b

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.05
System mass 2947.88 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 7n8b
Reference Zhao Yu, Rai Jay, Yu Hongguo, Li Hong. 2022. CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations Structure
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 3401
Chain BC / A1
Non-redundant True
Interacting RNA chains A/A1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A1: rRNA
RNA family global rRNA
Volume 227.75 Å3
Hydrophobicity 0.210
Hydrophilicity 0.943
Buriedness 0.629
Don/acc character 1.186
SiteScore 0.747
D Score 0.721
Kd