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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7bt6

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.12
System mass 2215.43 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 7bt6
Reference Wilson Daniel M., Li Yu, LaPeruta Amber, Gamalinda Michael, Gao Ning, Woolford John L.. 2020. Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel Nature Communications
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GTP
Residue . / 501
Chain YA / m
Non-redundant True
Interacting RNA chains SA/1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains SA/1: rRNA
RNA family global rRNA
Volume 357.41 Å3
Hydrophobicity 0.302
Hydrophilicity 1.991
Buriedness 0.891
Don/acc character 0.663
SiteScore 1.076
D Score 0.757
Kd