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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6yws

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.74
System mass 2367.41 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Neurospora
RCSB PDB Entry 6yws
Reference Itoh Yuzuru, Naschberger Andreas, Mortezaei Narges, Herrmann Johannes M., Amunts Alexey. 2020. Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi Nature Communications
Equivalence Class NR_all_72592.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 4301
Chain NH / 2
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 446.59 Å3
Hydrophobicity 0.009
Hydrophilicity 1.905
Buriedness 0.811
Don/acc character 0.413
SiteScore 0.901
D Score 0.581
Kd

Compound SPM
Residue . / 3661
Chain XG / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 865.39 Å3
Hydrophobicity 0.130
Hydrophilicity 1.777
Buriedness 0.851
Don/acc character 0.880
SiteScore 1.102
D Score 0.871
Kd