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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7nsi

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 4.60
System mass 3103.77 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Sus
RCSB PDB Entry 7nsi
Reference Kummer Eva, Schubert Katharina Noel, Schoenhut Tanja, Scaiola Alain, Ban Nenad. 2021. Structural basis of translation termination, rescue, and recycling in mammalian mitochondria Molecular Cell
Equivalence Class NR_all_24610.5, NR_all_19551.9
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 5GP
Residue . / 1792
Chain RO / BA
Non-redundant True
Interacting RNA chains DB/BA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains DB/BA: rRNA
RNA family global rRNA
Volume 399.60 Å3
Hydrophobicity 0.146
Hydrophilicity 1.756
Buriedness 0.640
Don/acc character 0.453
SiteScore 1.111
D Score 0.752
Kd

Compound SPM
Residue . / 3001
Chain ED / AA
Non-redundant True
Interacting RNA chains ZA/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains ZA/AA: rRNA
RNA family global rRNA
Volume 701.44 Å3
Hydrophobicity 0.138
Hydrophilicity 1.169
Buriedness 0.790
Don/acc character 2.509
SiteScore 1.212
D Score 1.033
Kd

Compound SPM
Residue . / 1793
Chain SO / BA
Non-redundant True
Interacting RNA chains DB/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains DB/BA: rRNA
RNA family global rRNA
Volume 634.21 Å3
Hydrophobicity 0.364
Hydrophilicity 1.196
Buriedness 0.806
Don/acc character 1.535
SiteScore 1.072
D Score 1.034
Kd

Compound SPM
Residue . / 1794
Chain TO / BA
Non-redundant True
Interacting RNA chains DB/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains DB/BA: rRNA
RNA family global rRNA
Volume 547.43 Å3
Hydrophobicity 0.169
Hydrophilicity 1.254
Buriedness 0.764
Don/acc character 0.905
SiteScore 1.044
D Score 0.990
Kd