Harnessing RIBOnucleic acid - Small molecules Structures
Human nuclear pre-60S ribosomal subunit (State I3)
SM: GTP
40S subunit of the Giardia lamblia 80S ribosome
SM: YAT
Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C)
SM: G4P
Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B)
SM: GCP
Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C)
Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution
SM: 6IF
40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V1 conformation
40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs.
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
SM: 3H3 ANM GSP
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)
SM: 3HE GSP HMT
SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP
SM: GNP
Cryo-EM structure of the the NS5-NS3 RNA-elongation complex
SM: CDP
Crystal structure of MnmM from B. subtilis complexed with Gln-TTG anti-codon stem loop and SAM (2.90 A)
SM: SAM
Crystal structure of MnmM from S. aureus complexed with SAM and tRNA anti-codon stem loop (ASL) (1.55 A)
Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome
Dibekacin-bound E.coli 70S ribosome in the PURE system
SM: 84D SPM
Arbekacin-bound E.coli 70S ribosome in the PURE system
SM: 84G SPM
Dibekacin-added human 80S ribosome
SM: 84D
Arbekacin-added human 80S ribosome
SM: 84G
Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide
SM: 3HE
Wheat 80S ribosome pausing on AUG-Stop with cycloheximide
Cryo-EM structure of the human 55S mitoribosome with Tigecycline
SM: T1C
Cryo-EM structure of the human 80S ribosome with Tigecycline
Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A
SM: GDP T1C
Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM)
SM: 3K5 PAR
Structure of Candida albicans 80S ribosome in complex with mefloquine
SM: SPK YMZ
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol)
Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM)
55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA
SM: SPM
28S mammalian mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA
Monkeypox virus VP39 in complex with SAH and cap0
SM: SAH
Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state)
SM: 3K5 GET
Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) bound with pre-let7g miRNA and UTPalphaS
SM: P5E
Ternary complex of translating ribosome, NAC and METAP1
Structural insights into human co-transcriptional capping - structure 6
Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells
SM: CLM SPM
Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit
Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells
Yeast 60S ribosomal subunit, RPL39 deletion
Mouse RPL39 integrated into the yeast 60S ribosomal subunit
Yeast 60S ribosomal subunit
Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S)
SM: CLM
Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S)
Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state)
SM: ATP
Mouse RPL39L integrated into the yeast 60S ribosomal subunit
Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A
SM: 2KH
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
SM: A0I
Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation)
Chaetomium thermophilum pre-60S State 6 - pre-5S rotation - L1 intermediate - composite structure
Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1
Chaetomium thermophilum pre-60S State 9 - pre-5S rotation - immature H68/H69 - composite structure
Chaetomium thermophilum pre-60S State 2 - pre-5S rotation with Rix1 complex - composite structure
Chaetomium thermophilum pre-60S State 8 - pre-5S rotation without Foot - composite structure
Chaetomium thermophilum pre-60S State 1 - pre-5S rotation (Arx1/Nog2 state) - Composite structure
Chaetomium thermophilum pre-60S State 5 - pre-5S rotation - L1 inward - composite structure
Chaetomium thermophilum pre-60S State 7 - pre-5S rotation lacking Utp30/ITS2 - composite structure
Structure of Candida albicans 80S ribosome in complex with cephaeline
SM: K16 SPK
mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 1
SM: NAD SPM SRY
mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 2
SM: NAD
Current selection range: to