Complex 8pnq
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 2.88 |
| System mass | 292.10 kDa |
| Deposition year | 2023 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Alphainfluenzavirus |
| RCSB PDB Entry | 8pnq |
| Reference | Krischuns Tim, Arragain Benoît, Isel Catherine, Paisant Sylvain, Budt Matthias, Wolff Thorsten, Cusack Stephen, Naffakh Nadia. 2024. The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome Nature Communications |
| Equivalence Class |
NR_all_31827.1
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 2KH |
| Residue | . / 801 |
| Chain | G / B |
| Non-redundant | True |
| Interacting RNA chains | D/V, E/M |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | D/V: unknown, E/M: unknown |
| RNA family global | unknown |
| Volume | 540.23 Å3 |
| Hydrophobicity | 0.169 |
| Hydrophilicity | 1.764 |
| Buriedness | 0.868 |
| Don/acc character | 0.642 |
| SiteScore | 1.114 |
| D Score | 0.886 |
| Kd | — |