Harnessing RIBOnucleic acid - Small molecules Structures
Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
SM: GE6
mt-SSU from Trypanosoma cruzi in complex with mt-IF-3.
SM: UTP
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.
NMR solution structures of CAG RNA-DB213 binding complex
SM: L94
Crystal structure of the Cas12i1 R-loop complex before target DNA cleavage
SM: CIT
Crystal structure of the Cas12i1 R-loop complex after target DNA cleavage
Crystal structure of the Cas12i1-crRNA binary complex
Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage
Interaction between a fluoroquinolone derivative and RNAs with a single bulge
SM: 53D
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM).
SM: SAM
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).
SM: SAH
Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (crystal form I)
SM: EPE
Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (native, crystal form I)
MiaB in the complex with s-adenosylmethionine and RNA
Methylated MiaB in the complex with 5'-deoxyadenosine, methionine and RNA
SM: 5AD ZKP
MiaB in the complex with 5'-deoxyadenosine, methionine and RNA
SM: 5AD
Escherichia coli RNA polymerase and RapA elongation complex
SM: 2TM
Escherichia coli RNA polymerase elongation complex
Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site
SM: DCP
Cycloheximide bound vacant 80S structure isolated from cbf5-D95A
SM: 3HE
Lassa virus L protein in an elongation conformation [ELONGATION]
SM: 2KH
La Crosse virus polymerase at transcription capped RNA cleavage stage
SM: ATP
La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site
La Crosse virus polymerase at replication initiation stage
Xist (m6A)UCG tetraloop RNA bound to the YTH domain of YTHDC1
SM: GTP
Structure of the pre state human RNA Polymerase I Elongation Complex
Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase
In situ structure of polymerase complex of mammalian reovirus in the elongation state
Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION]
SM: 2KH EPE
Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]
Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION]
M. tuberculosis RNAP pause escaped complex with Bacillus subtilis NusG and GMPCPP
SM: G2P
Cryo-EM consensus structure of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase plus preQ1 ligand
SM: PRF
Cryo-EM structure of 3DVA component 0 of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase plus preQ1 ligand
Cryo-EM structure of 3DVA component 1 of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase plus preQ1 ligand
Bombyx mori R2 retrotransposon initiating target-primed reverse transcription
SM: TTP
Structure of the Cas7-11-Csx29-guide RNA-target RNA (non-matching PFS) complex
SM: C5P
SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP
SM: GNP
Crystal structure of MnmM from B. subtilis complexed with Gln-TTG anti-codon stem loop and SAM (2.90 A)
Interaction between a fluoroquinolone derivative KG022 and RNAs: effect of base pairs 3' adjacent to the bulge out residues
Crystal structure of RhoBAST complexed with TMR-DN
SM: V8C
Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) bound with pre-let7g miRNA and UTPalphaS
SM: P5E
Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
SM: A0I
Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation)
Crystal structure of RNA G2C4 repeats in complex with small synthetic molecule ANP77
SM: W53
Tilapia Lake Virus polymerase in vRNA pre-termination state (transcriptase conformation)
Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition
SM: Y59
Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition
SM: Y53
Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION]
Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition
SM: YB3
SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate
SM: WSB
SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode
SM: VSN
Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active state (N-occupied)
Crystal structure of SARS-CoV-2 nsp16/nsp10 in complex with Cap-1 RNA
Cryo-EM structure of Thogoto virus polymerase in a transcription initiation conformation
Current selection range: to
