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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8ub7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.20
System mass 260.08 kDa
Deposition year 2023
Molecule type RNA/Protein
# RNA entities 1
Organism Rauchvirus
RCSB PDB Entry 8ub7
Reference Handa Sumit, Biswas Tapan, Chakraborty Jeet, Ghosh Gourisankar, Paul Blair G., Ghosh Partho. 2025. RNA control of reverse transcription in a diversity-generating retroelement Nature
Equivalence Class NR_all_58042.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DCP
Residue . / 401
Chain J / A
Non-redundant True
Interacting RNA chains H/H, I/I
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains H/H: unknown, I/I: unknown
RNA family global unknown
Volume 561.83 Å3
Hydrophobicity 0.443
Hydrophilicity 1.387
Buriedness 0.797
Don/acc character 0.610
SiteScore 1.066
D Score 0.966
Kd