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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8asd

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.60
System mass 265.75 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Bandavirus
RCSB PDB Entry 8asd
Reference Williams Harry M, Thorkelsson Sigurdur R, Vogel Dominik, Milewski Morlin, Busch Carola, Cusack Stephen, Grünewald Kay, Quemin Emmanuelle R J, Rosenthal Maria. 2023. Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein Nucleic Acids Research
Equivalence Class NR_all_42699.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 2KH
Residue . / 2104
Chain I / A
Non-redundant False
Interacting RNA chains B/T, C/G
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/T: unknown, C/G: unknown
RNA family global unknown
Volume 784.78 Å3
Hydrophobicity 0.240
Hydrophilicity 1.626
Buriedness 0.856
Don/acc character 0.576
SiteScore 1.106
D Score 0.924
Kd